ID   ARV1_DICDI              Reviewed;         246 AA.
AC   Q54GD9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein arv1 homolog;
GN   Name=arv1; ORFNames=DDB_G0290221;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC       trafficking and distribution into membranes. Regulates also the
CC       sphingolipid metabolism (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000161; EAL62332.1; -; Genomic_DNA.
DR   RefSeq; XP_635839.1; XM_630747.1.
DR   AlphaFoldDB; Q54GD9; -.
DR   STRING; 44689.DDB0305173; -.
DR   PaxDb; Q54GD9; -.
DR   EnsemblProtists; EAL62332; EAL62332; DDB_G0290221.
DR   GeneID; 8627547; -.
DR   KEGG; ddi:DDB_G0290221; -.
DR   dictyBase; DDB_G0290221; arv1.
DR   eggNOG; KOG3134; Eukaryota.
DR   HOGENOM; CLU_057366_1_0_1; -.
DR   InParanoid; Q54GD9; -.
DR   OMA; KITICDS; -.
DR   PhylomeDB; Q54GD9; -.
DR   Reactome; R-DDI-191273; Cholesterol biosynthesis.
DR   PRO; PR:Q54GD9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR   GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IBA:GO_Central.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IBA:GO_Central.
DR   GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR   InterPro; IPR007290; Arv1.
DR   PANTHER; PTHR14467; PTHR14467; 1.
DR   Pfam; PF04161; Arv1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Lipid metabolism;
KW   Lipid transport; Membrane; Reference proteome; Sphingolipid metabolism;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..246
FT                   /note="Protein arv1 homolog"
FT                   /id="PRO_0000328234"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   246 AA;  29084 MW;  7BE22607E6F04A74 CRC64;
     MICIECGRPV NDVYKEFGKA GSGNIRLTRC ASCNQTADKY VEYDFIIVFL DLFLHKAQAY
     RHLLFNRQPY RDFGIPIQYI KVLVVYIFFE SYIKWLRFKE YEQHPSGPAF YYIDWQDDVP
     YDRYWFIFVT AIAEFAVYIL SIILSVRFIY ESRYPIIKYN YLIMAIILSS FGKGFLVLMM
     IWDYPFSFGS ILNIFVLSSN VVAIKVFLDT TTFKAIFFVV FGFLGKLLFQ SIIYLFDASM
     LLHLSF