OOG1_MOUSE
ID OOG1_MOUSE Reviewed; 496 AA.
AC E9Q5G7; Q810D9;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Oogenesin-1 {ECO:0000303|PubMed:12890732};
GN Name=Oog1 {ECO:0000312|MGI:MGI:2679150};
GN Synonyms=Oog {ECO:0000312|MGI:MGI:2679150};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:BAB91151.3}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 114-496, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12890732; DOI=10.1095/biolreprod.103.018051;
RA Minami N., Aizawa A., Ihara R., Miyamoto M., Ohashi A., Imai H.;
RT "Oogenesin is a novel mouse protein expressed in oocytes and early
RT cleavage-stage embryos.";
RL Biol. Reprod. 69:1736-1742(2003).
RN [3] {ECO:0000305}
RP FUNCTION, INTERACTION WITH RALGDS AND HRAS, AND SUBCELLULAR LOCATION.
RX PubMed=16580637; DOI=10.1016/j.bbrc.2006.03.063;
RA Tsukamoto S., Ihara R., Aizawa A., Kishida S., Kikuchi A., Imai H.,
RA Minami N.;
RT "Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling
RT proteins during early embryogenesis.";
RL Biochem. Biophys. Res. Commun. 343:1105-1112(2006).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=29731491; DOI=10.1262/jrd.2018-024;
RA Honda S., Miki Y., Miyamoto Y., Kawahara Y., Tsukamoto S., Imai H.,
RA Minami N.;
RT "Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-
RT specific genes in oocytes.";
RL J. Reprod. Dev. 64:297-301(2018).
CC -!- FUNCTION: May down-regulate the expression of spermatogenesis-
CC associated genes in female germ cells allowing their normal
CC differentiation into oocytes (PubMed:29731491). May act as a Ras-
CC mediated signaling protein in early embryogenesis.
CC {ECO:0000269|PubMed:29731491, ECO:0000305|PubMed:16580637}.
CC -!- SUBUNIT: Interacts with RALGDS (via Ras-associating domain)
CC (PubMed:16580637). Interacts with HRAS (in GTP-bound form)
CC (PubMed:16580637). {ECO:0000269|PubMed:16580637}.
CC -!- INTERACTION:
CC E9Q5G7; Q03385: Ralgds; NbExp=5; IntAct=EBI-923698, EBI-923705;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12890732,
CC ECO:0000269|PubMed:16580637}. Cytoplasm {ECO:0000269|PubMed:12890732,
CC ECO:0000269|PubMed:16580637}. Note=In early one-cell embryos, exists
CC only in the cytoplasm and gradually moves to the nucleus at the middle
CC one-cell stage. At the late one-cell and early two-cell stages, higher
CC levels in nucleus than cytoplasm. After the middle two-cell stage,
CC mainly cytoplasmic and completely cytoplasmic after the four-cell
CC stage. {ECO:0000269|PubMed:12890732}.
CC -!- TISSUE SPECIFICITY: Expressed in the ovary, ovulated oocytes and
CC preimplantation embryos (at protein level). Not detected in testis,
CC liver, kidney, spleen, heart, lung and brain.
CC {ECO:0000269|PubMed:12890732, ECO:0000269|PubMed:29731491}.
CC -!- DEVELOPMENTAL STAGE: Expressed predominantly in oocytes and one- to
CC four-cell-stage embryos with weak expression in morula/blastocyst-stage
CC embryos (at protein level). Expression increases from oocyte to the
CC one-cell stage and then decreases toward the four-cell stage (at
CC protein level). Highly expressed in oocytes of primary, secondary and
CC antral follicles with low levels in oocytes of primordial follicles (at
CC protein level). {ECO:0000269|PubMed:12890732,
CC ECO:0000269|PubMed:29731491}.
CC -!- DISRUPTION PHENOTYPE: Expression of spermatogenesis-associated genes
CC including Klhl10, Tekt2, Tdrd6 and Tnp2 are significantly up-regulated
CC in the ovaries. {ECO:0000269|PubMed:29731491}.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB91151.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC126554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB050008; BAB91151.3; ALT_INIT; mRNA.
DR CCDS; CCDS49123.1; -.
DR RefSeq; NP_848772.3; NM_178657.5.
DR AlphaFoldDB; E9Q5G7; -.
DR SMR; E9Q5G7; -.
DR IntAct; E9Q5G7; 2.
DR STRING; 10090.ENSMUSP00000093165; -.
DR PaxDb; E9Q5G7; -.
DR PRIDE; E9Q5G7; -.
DR DNASU; 193322; -.
DR Ensembl; ENSMUST00000095509; ENSMUSP00000093165; ENSMUSG00000096576.
DR GeneID; 193322; -.
DR KEGG; mmu:193322; -.
DR CTD; 193322; -.
DR MGI; MGI:2679150; Oog1.
DR VEuPathDB; HostDB:ENSMUSG00000096576; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; E9Q5G7; -.
DR OrthoDB; 1660066at2759; -.
DR PhylomeDB; E9Q5G7; -.
DR TreeFam; TF332708; -.
DR BioGRID-ORCS; 193322; 4 hits in 19 CRISPR screens.
DR ChiTaRS; Oog1; mouse.
DR PRO; PR:E9Q5G7; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; E9Q5G7; protein.
DR Bgee; ENSMUSG00000096576; Expressed in animal zygote and 7 other tissues.
DR ExpressionAtlas; E9Q5G7; baseline and differential.
DR Genevisible; E9Q5G7; MM.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0048599; P:oocyte development; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..496
FT /note="Oogenesin-1"
FT /id="PRO_0000437074"
FT REPEAT 115..139
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 194..218
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 219..244
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 245..282
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 283..308
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 309..340
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 341..364
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 365..392
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 393..417
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 496 AA; 56633 MW; D80F528860AAF196 CRC64;
MVICLHCPDQ DDSLEEVTEE CYSPPTLQNL AIQSLLRDEA LAISALTDLP QSLFPVIFEE
AFTDGYIGIL KAMIPVWPFP YLSLGKQINN CNLETLKAML EGLDILLAQK VQTSRCKLRV
INWREDDLKI WAGSHEGEGL PDFRTEKQPI ENSAGCEVKK ELKVTTEVLR MKGRLDESTT
YLLQWAQQRK DSIHLFCRKL LIEGLTKASV IEIFKTVHAD CIQELILRCI CIEELAFLNP
YLKLMKSLFT LTLDHIIGTF SLGDSEKLDE ETIFSLISQL PTLHCLQKLY VNDVPFIKGN
LKEYLRCLKK PLETLCISNC DLSQSDLDCL PYCLNICELK HLHISDIYLC DLLLEPLGFL
LERVGDTLKT LELDSCCIVD FQFSALLPAL SQCSHLREVT FYDNDVSLPF LKQLLHHTAL
LSQLIYECYP APLECYDDSG VILTHRLESF CPELLDILRA KRQLHSVSFQ TTKCSKCGGC
YIYDRHTQCC RFVELL
