OOG2_MOUSE
ID OOG2_MOUSE Reviewed; 476 AA.
AC Q7TPX8;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Oogenesin-2 {ECO:0000303|PubMed:14675769};
GN Name=Oog2 {ECO:0000312|MGI:MGI:2684035};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X 129;
RX PubMed=14675769; DOI=10.1016/s0014-5793(03)01341-3;
RA Dade S., Callebaut I., Mermillod P., Monget P.;
RT "Identification of a new expanding family of genes characterized by
RT atypical LRR domains. Localization of a cluster preferentially expressed in
RT oocyte.";
RL FEBS Lett. 555:533-538(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- TISSUE SPECIFICITY: Expressed in ovary, specifically in oocytes.
CC Detected in follicles with two layers of granulosa cells, and are
CC present in early as well as large antral follicles.
CC {ECO:0000269|PubMed:14675769}.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AY573562; AAS99140.1; -; mRNA.
DR EMBL; AL627131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052839; AAH52839.1; -; mRNA.
DR CCDS; CCDS18901.1; -.
DR RefSeq; NP_941063.1; NM_198661.3.
DR AlphaFoldDB; Q7TPX8; -.
DR SMR; Q7TPX8; -.
DR STRING; 10090.ENSMUSP00000079267; -.
DR PaxDb; Q7TPX8; -.
DR PRIDE; Q7TPX8; -.
DR Ensembl; ENSMUST00000080405; ENSMUSP00000079267; ENSMUSG00000066030.
DR GeneID; 381570; -.
DR KEGG; mmu:381570; -.
DR UCSC; uc008vqy.2; mouse.
DR CTD; 381570; -.
DR MGI; MGI:2684035; Oog2.
DR VEuPathDB; HostDB:ENSMUSG00000066030; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q7TPX8; -.
DR OrthoDB; 898558at2759; -.
DR PhylomeDB; Q7TPX8; -.
DR TreeFam; TF332708; -.
DR BioGRID-ORCS; 381570; 1 hit in 38 CRISPR screens.
DR ChiTaRS; Oog2; mouse.
DR PRO; PR:Q7TPX8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q7TPX8; protein.
DR Bgee; ENSMUSG00000066030; Expressed in animal zygote and 6 other tissues.
DR ExpressionAtlas; Q7TPX8; baseline and differential.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..476
FT /note="Oogenesin-2"
FT /id="PRO_0000440972"
FT REPEAT 97..121
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 176..200
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 201..226
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 227..264
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 265..285
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 286..317
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 342..369
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 370..394
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 476 AA; 55091 MW; 52CFEDB9C9EDDD4B CRC64;
MNFYSPPTLM ELARQCLLRD EYLAISALKD LPNMMFPVMF KEAFIDGHTK ILTAMIPVWP
FPYLSVGTML KNLNLDTLKA VLEEIDILIS KPVFSSRCKL REITLSHDLV VVWAGSHEVE
GLPEFMEQEK PVENSPGYGT KNKLKVTTEL QFMEGHLDEC STYLLQWAYQ REDSIHLHCR
KLKIYGLTKA AVIEMFKIVH AEYIEDLELS CLCLEYLDFL NPYLKQMSNL LSLTLDEIIY
TLNIDDYRNL NEEKVITVIS HLPTFHHLQE LYVHGVIFIE CLRCLKKPLE VLSFTDCDLS
QSDLDYLPYC LNIFELRSLH LTDVRLSNLL LEPLGFLLER VRHTLKSLQL MSCEMGETHF
NALLPALSQC YQLTVVNFYG NELSLLFLKK LLHHTAKLSQ LADELYPAPQ ECYDNRDVVL
SHRLENFCSE LLDILRAIRE PKKVTFGTIK CSKCGGSYVY DLETQCCFFE KNPPWA
