OOG3_MOUSE
ID OOG3_MOUSE Reviewed; 500 AA.
AC Q3UWY1; Q7TPT9;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Oogenesin-3 {ECO:0000312|Ensembl:ENSMUSP00000059834};
GN Name=Oog3 {ECO:0000312|MGI:MGI:2684047};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION OF LRR REPEATS, AND
RP TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X 129;
RX PubMed=14675769; DOI=10.1016/s0014-5793(03)01341-3;
RA Dade S., Callebaut I., Mermillod P., Monget P.;
RT "Identification of a new expanding family of genes characterized by
RT atypical LRR domains. Localization of a cluster preferentially expressed in
RT oocyte.";
RL FEBS Lett. 555:533-538(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UWY1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UWY1-2; Sequence=VSP_059016;
CC -!- TISSUE SPECIFICITY: Expressed in ovary, specifically in oocytes.
CC Detected in follicles with two layers of granulosa cells, and are
CC present in early as well as large antral follicles.
CC {ECO:0000269|PubMed:14675769}.
CC -!- SIMILARITY: Belongs to the PRAME family. {ECO:0000305}.
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DR EMBL; AY573563; AAS99141.1; -; mRNA.
DR EMBL; AK136030; BAE22783.1; -; mRNA.
DR EMBL; AL627131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053700; AAH53700.1; -; mRNA.
DR CCDS; CCDS51361.1; -. [Q3UWY1-1]
DR RefSeq; NP_957710.2; NM_201258.2. [Q3UWY1-1]
DR AlphaFoldDB; Q3UWY1; -.
DR SMR; Q3UWY1; -.
DR STRING; 10090.ENSMUSP00000059834; -.
DR PhosphoSitePlus; Q3UWY1; -.
DR PaxDb; Q3UWY1; -.
DR PRIDE; Q3UWY1; -.
DR Ensembl; ENSMUST00000050933; ENSMUSP00000059834; ENSMUSG00000050810. [Q3UWY1-1]
DR GeneID; 100012; -.
DR KEGG; mmu:100012; -.
DR UCSC; uc008vqx.2; mouse. [Q3UWY1-1]
DR CTD; 100012; -.
DR MGI; MGI:2684047; Oog3.
DR VEuPathDB; HostDB:ENSMUSG00000050810; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR GeneTree; ENSGT01030000234531; -.
DR HOGENOM; CLU_039635_2_1_1; -.
DR InParanoid; Q3UWY1; -.
DR OMA; ENSPECE; -.
DR OrthoDB; 898558at2759; -.
DR PhylomeDB; Q3UWY1; -.
DR TreeFam; TF332708; -.
DR BioGRID-ORCS; 100012; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Oog3; mouse.
DR PRO; PR:Q3UWY1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3UWY1; protein.
DR Bgee; ENSMUSG00000050810; Expressed in primary oocyte and 7 other tissues.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR026271; PRAME_family.
DR PIRSF; PIRSF038286; PRAME; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..500
FT /note="Oogenesin-3"
FT /id="PRO_0000440973"
FT REPEAT 116..143
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 198..222
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 223..248
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 249..285
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 286..311
FT /note="LRR 5"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 312..343
FT /note="LRR 6"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 344..367
FT /note="LRR 7"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 368..395
FT /note="LRR 8"
FT /evidence="ECO:0000303|PubMed:14675769"
FT REPEAT 396..420
FT /note="LRR 9"
FT /evidence="ECO:0000303|PubMed:14675769"
FT VAR_SEQ 1..52
FT /note="Missing (in isoform 2)"
FT /id="VSP_059016"
SQ SEQUENCE 500 AA; 57407 MW; E7169CFE7FF28431 CRC64;
MMICHQCLDQ DDSSEEEEAV SVYSPSTLVK LARQRLLREE ALVISALKGL PNMLFPVIFE
EAFINGHTKI LKAMIPMWPF PYLSVGALTN NCNLKTLKAV LDGLDILLAQ KVRSSRCKLR
VLKWRDEQHD FCGIWPGSHE AEDLPELMTQ KHPVQNNPDC GVKKELRVTT ELSVMKGRLD
DSATYLLEWA QQRKDSIHLL CRKLVIETLT KDTVIEIFKI VNADCIQELE LYSLCLEDLA
FLNPYLRQMD NLLELTLDHV TDSLSMGDSE MCEEEMITLV SQLPTFPCLQ KLCVNDVYFI
YGNLNEILRC LKKPLVSFCI SNCELSQSDL DCLPYCLNIF ELKCLYLIDI PLNHLCLDPL
GFLLESVRHT LECLELKSCD MGEPQFNALL PALSQCSHLT DVSFWENELS LLFLKQLLQH
TSKLTQLSYE LYPAPLECYD DRGLILSHRL EQFCPELLDI LRAKRQPKDI AFVTNPCSKC
GRYYVYDPKT QRFSLEDTTL
