ARV1_HUMAN
ID ARV1_HUMAN Reviewed; 271 AA.
AC Q9H2C2; A8KAI4; Q5VSN7; Q5VSN8; Q5VSN9; Q5VSP0; Q5VSP2; Q9H2H2; Q9H5V6;
AC Q9UFF5;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Protein ARV1;
DE Short=hARV1;
GN Name=ARV1; ORFNames=HT035;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND POSSIBLE FUNCTION.
RX PubMed=11063737; DOI=10.1074/jbc.c000710200;
RA Tinkelenberg A.H., Liu Y., Alcantara F., Khan S., Guo Z., Bard M.,
RA Sturley S.L.;
RT "Mutations in yeast ARV1 alter intracellular sterol distribution and are
RT complemented by human ARV1.";
RL J. Biol. Chem. 275:40667-40670(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA He Y., Tan D., Lai J., Xie Y., Qian W., Yu M., He J.;
RT "Cloning and analysis of a G1/S and G2/M phase transition related
RT protein.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hypothalamus;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-271.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP POSSIBLE FUNCTION.
RX PubMed=12145310; DOI=10.1074/jbc.m206624200;
RA Swain E., Stukey J., McDonough V., Germann M., Liu Y., Sturley S.L.,
RA Nickels J.T. Jr.;
RT "Yeast cells lacking the ARV1 gene harbor defects in sphingolipid
RT metabolism. Complementation by human ARV1.";
RL J. Biol. Chem. 277:36152-36160(2002).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20663892; DOI=10.1074/jbc.m110.165761;
RA Tong F., Billheimer J., Shechtman C.F., Liu Y., Crooke R., Graham M.,
RA Cohen D.E., Sturley S.L., Rader D.J.;
RT "Decreased expression of ARV1 results in cholesterol retention in the
RT endoplasmic reticulum and abnormal bile acid metabolism.";
RL J. Biol. Chem. 285:33632-33641(2010).
RN [11]
RP VARIANT DEE38 ARG-189, AND INVOLVEMENT IN DEE38.
RX PubMed=25558065; DOI=10.1016/j.celrep.2014.12.015;
RA Alazami A.M., Patel N., Shamseldin H.E., Anazi S., Al-Dosari M.S.,
RA Alzahrani F., Hijazi H., Alshammari M., Aldahmesh M.A., Salih M.A.,
RA Faqeih E., Alhashem A., Bashiri F.A., Al-Owain M., Kentab A.Y., Sogaty S.,
RA Al Tala S., Temsah M.H., Tulbah M., Aljelaify R.F., Alshahwan S.A.,
RA Seidahmed M.Z., Alhadid A.A., Aldhalaan H., Alqallaf F., Kurdi W.,
RA Alfadhel M., Babay Z., Alsogheer M., Kaya N., Al-Hassnan Z.N.,
RA Abdel-Salam G.M., Al-Sannaa N., Al Mutairi F., El Khashab H.Y., Bohlega S.,
RA Jia X., Nguyen H.C., Hammami R., Adly N., Mohamed J.Y., Abdulwahab F.,
RA Ibrahim N., Naim E.A., Al-Younes B., Meyer B.F., Hashem M., Shaheen R.,
RA Xiong Y., Abouelhoda M., Aldeeri A.A., Monies D.M., Alkuraya F.S.;
RT "Accelerating novel candidate gene discovery in neurogenetic disorders via
RT whole-exome sequencing of prescreened multiplex consanguineous families.";
RL Cell Rep. 10:148-161(2015).
RN [12]
RP VARIANTS DEE38 59-LYS--ASN-98 DEL AND ARG-189, AND CHARACTERIZATION OF
RP VARIANTS DEE38 59-LYS--ASN-98 AND ARG-189.
RX PubMed=27270415; DOI=10.1093/hmg/ddw157;
RA Palmer E.E., Jarrett K.E., Sachdev R.K., Al Zahrani F., Hashem M.O.,
RA Ibrahim N., Sampaio H., Kandula T., Macintosh R., Gupta R., Conlon D.M.,
RA Billheimer J.T., Rader D.J., Funato K., Walkey C.J., Lee C.S., Loo C.,
RA Brammah S., Elakis G., Zhu Y., Buckley M., Kirk E.P., Bye A.,
RA Alkuraya F.S., Roscioli T., Lagor W.R.;
RT "Neuronal deficiency of ARV1 causes an autosomal recessive epileptic
RT encephalopathy.";
RL Hum. Mol. Genet. 25:3042-3054(2016).
CC -!- FUNCTION: Plays a role as a mediator in the endoplasmic reticulum (ER)
CC cholesterol and bile acid homeostasis (PubMed:11063737,
CC PubMed:12145310, PubMed:20663892). Participates in sterol transport out
CC of the ER and distribution into plasma membranes (PubMed:20663892).
CC {ECO:0000269|PubMed:11063737, ECO:0000269|PubMed:12145310,
CC ECO:0000269|PubMed:20663892}.
CC -!- INTERACTION:
CC Q9H2C2; Q13520: AQP6; NbExp=3; IntAct=EBI-11724186, EBI-13059134;
CC Q9H2C2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-11724186, EBI-6942903;
CC Q9H2C2; Q15125: EBP; NbExp=3; IntAct=EBI-11724186, EBI-3915253;
CC Q9H2C2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-11724186, EBI-18304435;
CC Q9H2C2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11724186, EBI-13345167;
CC Q9H2C2; P15941-11: MUC1; NbExp=3; IntAct=EBI-11724186, EBI-17263240;
CC Q9H2C2; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-11724186, EBI-18397230;
CC Q9H2C2; Q9NY72: SCN3B; NbExp=4; IntAct=EBI-11724186, EBI-17247926;
CC Q9H2C2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-11724186, EBI-18159983;
CC Q9H2C2; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-11724186, EBI-12947623;
CC Q9H2C2; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-11724186, EBI-8638294;
CC Q9H2C2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-11724186, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:20663892}; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highly expressed in liver and adipose.
CC {ECO:0000269|PubMed:20663892}.
CC -!- DISEASE: Developmental and epileptic encephalopathy 38 (DEE38)
CC [MIM:617020]: A form of epileptic encephalopathy, a heterogeneous group
CC of severe early-onset epilepsies characterized by refractory seizures,
CC neurodevelopmental impairment, and poor prognosis. Development is
CC normal prior to seizure onset, after which cognitive and motor delays
CC become apparent. DEE38 inheritance is autosomal recessive.
CC {ECO:0000269|PubMed:25558065, ECO:0000269|PubMed:27270415}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- MISCELLANEOUS: When transfected in S.cerevisiae, it can complement the
CC absence of yeast of ARV1 protein, suggesting a conserved role in
CC sphingolipid metabolism. {ECO:0000269|PubMed:11063737,
CC ECO:0000269|PubMed:12145310}.
CC -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15513.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AF290878; AAG47671.1; -; mRNA.
DR EMBL; AF321442; AAK11180.1; -; mRNA.
DR EMBL; AF271780; AAG44791.1; -; mRNA.
DR EMBL; AK026629; BAB15513.1; ALT_SEQ; mRNA.
DR EMBL; AK293049; BAF85738.1; -; mRNA.
DR EMBL; AL732414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471098; EAW69935.1; -; Genomic_DNA.
DR EMBL; BC016309; AAH16309.1; -; mRNA.
DR EMBL; AL122047; CAB59183.3; -; mRNA.
DR CCDS; CCDS1589.1; -.
DR PIR; T34534; T34534.
DR RefSeq; NP_001333921.1; NM_001346992.1.
DR RefSeq; NP_073623.1; NM_022786.2.
DR AlphaFoldDB; Q9H2C2; -.
DR BioGRID; 122307; 60.
DR IntAct; Q9H2C2; 31.
DR MINT; Q9H2C2; -.
DR STRING; 9606.ENSP00000312458; -.
DR TCDB; 9.A.19.1.2; the lipid intermediate transporter (arv1) family.
DR iPTMnet; Q9H2C2; -.
DR PhosphoSitePlus; Q9H2C2; -.
DR BioMuta; ARV1; -.
DR DMDM; 74752603; -.
DR EPD; Q9H2C2; -.
DR jPOST; Q9H2C2; -.
DR MassIVE; Q9H2C2; -.
DR MaxQB; Q9H2C2; -.
DR PaxDb; Q9H2C2; -.
DR PeptideAtlas; Q9H2C2; -.
DR PRIDE; Q9H2C2; -.
DR ProteomicsDB; 80527; -.
DR Antibodypedia; 34681; 100 antibodies from 21 providers.
DR DNASU; 64801; -.
DR Ensembl; ENST00000310256.7; ENSP00000312458.2; ENSG00000173409.14.
DR GeneID; 64801; -.
DR KEGG; hsa:64801; -.
DR MANE-Select; ENST00000310256.7; ENSP00000312458.2; NM_022786.3; NP_073623.1.
DR UCSC; uc001huh.4; human.
DR CTD; 64801; -.
DR DisGeNET; 64801; -.
DR GeneCards; ARV1; -.
DR HGNC; HGNC:29561; ARV1.
DR HPA; ENSG00000173409; Low tissue specificity.
DR MalaCards; ARV1; -.
DR MIM; 611647; gene.
DR MIM; 617020; phenotype.
DR neXtProt; NX_Q9H2C2; -.
DR OpenTargets; ENSG00000173409; -.
DR Orphanet; 442835; Non-specific early-onset epileptic encephalopathy.
DR PharmGKB; PA134935092; -.
DR VEuPathDB; HostDB:ENSG00000173409; -.
DR eggNOG; KOG3134; Eukaryota.
DR GeneTree; ENSGT00390000002675; -.
DR InParanoid; Q9H2C2; -.
DR OMA; KITICDS; -.
DR OrthoDB; 1466379at2759; -.
DR PhylomeDB; Q9H2C2; -.
DR TreeFam; TF105845; -.
DR PathwayCommons; Q9H2C2; -.
DR Reactome; R-HSA-191273; Cholesterol biosynthesis.
DR SignaLink; Q9H2C2; -.
DR BioGRID-ORCS; 64801; 14 hits in 1078 CRISPR screens.
DR ChiTaRS; ARV1; human.
DR GenomeRNAi; 64801; -.
DR Pharos; Q9H2C2; Tbio.
DR PRO; PR:Q9H2C2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9H2C2; protein.
DR Bgee; ENSG00000173409; Expressed in cardiac muscle of right atrium and 190 other tissues.
DR ExpressionAtlas; Q9H2C2; baseline and differential.
DR Genevisible; Q9H2C2; HS.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015248; F:sterol transporter activity; TAS:Reactome.
DR GO; GO:0008206; P:bile acid metabolic process; IEA:Ensembl.
DR GO; GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
DR GO; GO:0030301; P:cholesterol transport; IEA:Ensembl.
DR GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR GO; GO:0090181; P:regulation of cholesterol metabolic process; IMP:UniProtKB.
DR GO; GO:0032383; P:regulation of intracellular cholesterol transport; IMP:UniProtKB.
DR GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IBA:GO_Central.
DR GO; GO:0006665; P:sphingolipid metabolic process; IBA:GO_Central.
DR GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR InterPro; IPR007290; Arv1.
DR PANTHER; PTHR14467; PTHR14467; 1.
DR Pfam; PF04161; Arv1; 1.
PE 1: Evidence at protein level;
KW Cholesterol metabolism; Disease variant; Endoplasmic reticulum; Epilepsy;
KW Lipid metabolism; Lipid transport; Membrane; Reference proteome;
KW Steroid metabolism; Sterol metabolism; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..271
FT /note="Protein ARV1"
FT /id="PRO_0000228659"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 59..98
FT /note="Missing (in DEE38; loss of protein stability; yeast
FT complementation assays show that the variant does not
FT rescue cell growth)"
FT /evidence="ECO:0000269|PubMed:27270415"
FT /id="VAR_077050"
FT VARIANT 101
FT /note="G -> E (in dbSNP:rs35764859)"
FT /id="VAR_033525"
FT VARIANT 189
FT /note="G -> R (in DEE38; loss of protein stability; yeast
FT complementation assays show that the variant does partially
FT rescue cell growth; dbSNP:rs730882241)"
FT /evidence="ECO:0000269|PubMed:25558065,
FT ECO:0000269|PubMed:27270415"
FT /id="VAR_077051"
FT CONFLICT 135..136
FT /note="AK -> VR (in Ref. 4; BAB15513)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="A -> D (in Ref. 2; AAG44791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31052 MW; 35C065EB00FD4671 CRC64;
MGNGGRSGLQ QGKGNVDGVA ATPTAASASC QYRCIECNQE AKELYRDYNH GVLKITICKS
CQKPVDKYIE YDPVIILINA ILCKAQAYRH ILFNTQINIH GKLCIFCLLC EAYLRWWQLQ
DSNQNTAPDD LIRYAKEWDF YRMFAIAALE QTAYFIGIFT FLWVERPMTA KKKPNFILLL
KALLLSSYGK LLLIPAVIWE HDYTSVCLKL IKVFVLTSNF QAIRVTLNIN RKLSFLAVLS
GLLLESIMVY FFQSMEWDVG SDYAIFKSQD F
