OOSP1_MOUSE
ID OOSP1_MOUSE Reviewed; 202 AA.
AC Q925U0; Q3TSD1; Q8K4N9;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Oocyte-secreted protein 1;
DE AltName: Full=Initiate factor 3;
DE Flags: Precursor;
GN Name=Oosp1; Synonyms=If3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Oocyte;
RX PubMed=11747200; DOI=10.1002/gene.10010;
RA Yan C., Pendola F.L., Jacob R., Lau A.L., Eppig J.J., Matzuk M.M.;
RT "Oosp1 encodes a novel mouse oocyte-secreted protein.";
RL Genesis 31:105-110(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC TISSUE=Oocyte;
RX PubMed=12237121; DOI=10.1016/s0006-291x(02)02194-0;
RA Mano H., Nakatani S., Aoyagi R., Ishii R., Iwai Y., Shimoda N., Jincho Y.,
RA Hiura H., Hirose M., Mochizuki C., Yuri M., Hyock Im R., Funada-Wada U.,
RA Wada M.;
RT "IF3, a novel cell-differentiation factor, highly expressed in murine liver
RT and ovary.";
RL Biochem. Biophys. Res. Commun. 297:323-328(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in cell differentiation.
CC {ECO:0000269|PubMed:12237121}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q925U0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q925U0-2; Sequence=VSP_034664, VSP_034665;
CC -!- TISSUE SPECIFICITY: Expressed in oocytes in primary through antral-
CC stage follicles. Expressed in liver and ovary.
CC {ECO:0000269|PubMed:11747200, ECO:0000269|PubMed:12237121}.
CC -!- DEVELOPMENTAL STAGE: Expressed in preimplantation embryo. Expressed in
CC liver at 16 dpc but not at 13 dpc. {ECO:0000269|PubMed:12237121}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLAC1 family. {ECO:0000305}.
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DR EMBL; AF420487; AAL82591.1; -; mRNA.
DR EMBL; AB050982; BAB47553.1; -; mRNA.
DR EMBL; AB086437; BAC11848.1; -; mRNA.
DR EMBL; AK033038; BAC28135.1; -; mRNA.
DR EMBL; AK162132; BAE36744.1; -; mRNA.
DR EMBL; BC100313; AAI00314.1; -; mRNA.
DR CCDS; CCDS29607.1; -. [Q925U0-1]
DR RefSeq; NP_579931.1; NM_133353.3. [Q925U0-1]
DR AlphaFoldDB; Q925U0; -.
DR SMR; Q925U0; -.
DR STRING; 10090.ENSMUSP00000036529; -.
DR PaxDb; Q925U0; -.
DR PRIDE; Q925U0; -.
DR DNASU; 170834; -.
DR Ensembl; ENSMUST00000048214; ENSMUSP00000036529; ENSMUSG00000041857. [Q925U0-1]
DR Ensembl; ENSMUST00000139158; ENSMUSP00000123469; ENSMUSG00000041857. [Q925U0-2]
DR GeneID; 170834; -.
DR KEGG; mmu:170834; -.
DR UCSC; uc008gst.1; mouse. [Q925U0-1]
DR CTD; 255649; -.
DR MGI; MGI:2149290; Oosp1.
DR VEuPathDB; HostDB:ENSMUSG00000041857; -.
DR eggNOG; ENOG502T3UK; Eukaryota.
DR GeneTree; ENSGT00530000064049; -.
DR HOGENOM; CLU_117245_0_0_1; -.
DR InParanoid; Q925U0; -.
DR OMA; TYRTYSC; -.
DR OrthoDB; 1365568at2759; -.
DR PhylomeDB; Q925U0; -.
DR TreeFam; TF338479; -.
DR BioGRID-ORCS; 170834; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Oosp1; mouse.
DR PRO; PR:Q925U0; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q925U0; protein.
DR Bgee; ENSMUSG00000041857; Expressed in secondary oocyte and 31 other tissues.
DR ExpressionAtlas; Q925U0; baseline and differential.
DR Genevisible; Q925U0; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR033218; Oosp1/3/4.
DR InterPro; IPR033222; PLAC1_fam.
DR PANTHER; PTHR14380; PTHR14380; 1.
DR PANTHER; PTHR14380:SF3; PTHR14380:SF3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..202
FT /note="Oocyte-secreted protein 1"
FT /id="PRO_0000343689"
FT REGION 157..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 87..92
FT /note="VLCDVT -> SESSFL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12237121"
FT /id="VSP_034664"
FT VAR_SEQ 93..202
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12237121"
FT /id="VSP_034665"
FT CONFLICT 50
FT /note="M -> K (in Ref. 3; BAE36744)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 23013 MW; 6CD040EF26BB95FB CRC64;
MKPFVGLLGL LLLLSFMKTC ADDWTAISLQ CADHWFHLRI RPTIFHNIFM EPDEVFLGIG
CPVTTTWPND TYEFIYRTYS CGIANKVLCD VTLLKTQLTY ISKNASLQAE MSLSCVMHNQ
SPHFCEAESR GDFTGDPPGW TEDMRARRDE QTVPMVQPNL STSSEDHHVS TEPWASETSR
SEAAEVPSFM DQNFSVFHFS RM
