OOSP2_HUMAN
ID OOSP2_HUMAN Reviewed; 158 AA.
AC Q86WS3; E9PJA4; Q8N9U6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Oocyte-secreted protein 2;
DE AltName: Full=Placenta-specific 1-like protein;
DE AltName: Full=Protein TMEM122;
DE Flags: Precursor;
GN Name=OOSP2; Synonyms=PLAC1L, TMEM122;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86WS3; P42858: HTT; NbExp=9; IntAct=EBI-25888682, EBI-466029;
CC Q86WS3; P49768-2: PSEN1; NbExp=3; IntAct=EBI-25888682, EBI-11047108;
CC Q86WS3; P37840: SNCA; NbExp=3; IntAct=EBI-25888682, EBI-985879;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLAC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AP000790; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK093517; BAC04191.1; -; mRNA.
DR EMBL; AP000790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036256; AAH36256.1; -; mRNA.
DR EMBL; BC048121; AAH48121.1; -; mRNA.
DR CCDS; CCDS7979.1; -.
DR RefSeq; NP_776162.2; NM_173801.4.
DR AlphaFoldDB; Q86WS3; -.
DR SMR; Q86WS3; -.
DR BioGRID; 128614; 1.
DR IntAct; Q86WS3; 3.
DR STRING; 9606.ENSP00000278855; -.
DR iPTMnet; Q86WS3; -.
DR PhosphoSitePlus; Q86WS3; -.
DR BioMuta; OOSP2; -.
DR MassIVE; Q86WS3; -.
DR PaxDb; Q86WS3; -.
DR PeptideAtlas; Q86WS3; -.
DR PRIDE; Q86WS3; -.
DR TopDownProteomics; Q86WS3; -.
DR Antibodypedia; 27843; 61 antibodies from 18 providers.
DR DNASU; 219990; -.
DR Ensembl; ENST00000278855.7; ENSP00000278855.2; ENSG00000149507.7.
DR Ensembl; ENST00000647205.2; ENSP00000494787.1; ENSG00000285422.2.
DR GeneID; 219990; -.
DR KEGG; hsa:219990; -.
DR MANE-Select; ENST00000278855.7; ENSP00000278855.2; NM_173801.5; NP_776162.2.
DR UCSC; uc001nol.4; human.
DR CTD; 219990; -.
DR GeneCards; OOSP2; -.
DR HGNC; HGNC:26699; OOSP2.
DR HPA; ENSG00000149507; Tissue enriched (testis).
DR neXtProt; NX_Q86WS3; -.
DR OpenTargets; ENSG00000149507; -.
DR PharmGKB; PA162399666; -.
DR VEuPathDB; HostDB:ENSG00000149507; -.
DR eggNOG; ENOG502T865; Eukaryota.
DR GeneTree; ENSGT00530000064049; -.
DR HOGENOM; CLU_1717534_0_0_1; -.
DR InParanoid; Q86WS3; -.
DR OMA; FQTEMYF; -.
DR OrthoDB; 1276986at2759; -.
DR PhylomeDB; Q86WS3; -.
DR TreeFam; TF338479; -.
DR PathwayCommons; Q86WS3; -.
DR SignaLink; Q86WS3; -.
DR BioGRID-ORCS; 219990; 7 hits in 1050 CRISPR screens.
DR GenomeRNAi; 219990; -.
DR Pharos; Q86WS3; Tdark.
DR PRO; PR:Q86WS3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86WS3; protein.
DR Bgee; ENSG00000149507; Expressed in right testis and 18 other tissues.
DR ExpressionAtlas; Q86WS3; baseline and differential.
DR Genevisible; Q86WS3; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR033219; Oosp2.
DR InterPro; IPR033222; PLAC1_fam.
DR PANTHER; PTHR14380; PTHR14380; 1.
DR PANTHER; PTHR14380:SF7; PTHR14380:SF7; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..158
FT /note="Oocyte-secreted protein 2"
FT /id="PRO_0000251150"
FT CONFLICT 33
FT /note="V -> A (in Ref. 1; BAC04191)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 158 AA; 17971 MW; EEB43D6FB8AB81FF CRC64;
MALEVLMLLA VLIWTGAENL HVKISCSLDW LMVSVIPVAE SRNLYIFADE LHLGMGCPAN
RIHTYVYEFI YLVRDCGIRT RVVSEETLLF QTELYFTPRN IDHDPQEIHL ECSTSRKSVW
LTPVSTENEI KLDPSPFIAD FQTTAEELGL LSSSPNLL
