OOSP2_MOUSE
ID OOSP2_MOUSE Reviewed; 168 AA.
AC Q4FZG8; Q3UPM7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Oocyte-secreted protein 2;
DE AltName: Full=Placenta-specific 1-like protein;
DE Flags: Precursor;
GN Name=Oosp2; Synonyms=Gm99, Plac1l, Tmem122;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-168.
RC TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLAC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH99498.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK143411; BAE25368.1; -; mRNA.
DR EMBL; BC099498; AAH99498.1; ALT_INIT; mRNA.
DR CCDS; CCDS29606.1; -.
DR RefSeq; NP_001032723.1; NM_001037634.3.
DR AlphaFoldDB; Q4FZG8; -.
DR SMR; Q4FZG8; -.
DR STRING; 10090.ENSMUSP00000113931; -.
DR PhosphoSitePlus; Q4FZG8; -.
DR PaxDb; Q4FZG8; -.
DR PRIDE; Q4FZG8; -.
DR Antibodypedia; 27843; 61 antibodies from 18 providers.
DR Ensembl; ENSMUST00000121793; ENSMUSP00000113931; ENSMUSG00000055895.
DR GeneID; 225922; -.
DR KEGG; mmu:225922; -.
DR UCSC; uc008gss.1; mouse.
DR CTD; 219990; -.
DR MGI; MGI:2684945; Oosp2.
DR VEuPathDB; HostDB:ENSMUSG00000055895; -.
DR eggNOG; ENOG502T865; Eukaryota.
DR GeneTree; ENSGT00530000064049; -.
DR HOGENOM; CLU_1717534_0_0_1; -.
DR InParanoid; Q4FZG8; -.
DR OMA; FQTEMYF; -.
DR OrthoDB; 1276986at2759; -.
DR PhylomeDB; Q4FZG8; -.
DR TreeFam; TF338479; -.
DR BioGRID-ORCS; 225922; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Oosp2; mouse.
DR PRO; PR:Q4FZG8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q4FZG8; protein.
DR Bgee; ENSMUSG00000055895; Expressed in primary oocyte and 34 other tissues.
DR ExpressionAtlas; Q4FZG8; baseline and differential.
DR Genevisible; Q4FZG8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR033219; Oosp2.
DR InterPro; IPR033222; PLAC1_fam.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14380; PTHR14380; 1.
DR PANTHER; PTHR14380:SF7; PTHR14380:SF7; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..168
FT /note="Oocyte-secreted protein 2"
FT /id="PRO_0000251151"
SQ SEQUENCE 168 AA; 19223 MW; 9B1DC745A4A92B89 CRC64;
MGVSMALEVL VYLAVLVWTC AWDIDVDVSC SQDWMTVSVS AFSQNKRNPY IFADELYLGQ
NCRVTQIHAH QYDFIYPVSH CGIRTKVISN EIVCFETEMY FRPRNYCLEL QIVPLQCSAS
RKSVWLMPLS TEEDPKPVKS PFMTDFEATP EELGLLNAHQ AASSQNKR
