OP164_ARATH
ID OP164_ARATH Reviewed; 136 AA.
AC Q9LZH8;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Outer envelope pore protein 16-4, chloroplastic;
DE AltName: Full=Chloroplastic outer envelope pore protein of 16 kDa 4;
DE Short=AtOEP16-4;
DE Short=OEP16-4;
GN Name=OEP164; OrderedLocusNames=At3g62880; ORFNames=F26K9.310;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12649433; DOI=10.1110/ps.0237503;
RA Schleiff E., Eichacker L.A., Eckart K., Becker T., Mirus O., Stahl T.,
RA Soll J.;
RT "Prediction of the plant beta-barrel proteome: a case study of the
RT chloroplast outer envelope.";
RL Protein Sci. 12:748-759(2003).
RN [6]
RP SUBCELLULAR LOCATION, AND REVIEW.
RX PubMed=17098851; DOI=10.1104/pp.106.090688;
RA Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M.,
RA Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.;
RT "Characterization of the preprotein and amino acid transporter gene family
RT in Arabidopsis.";
RL Plant Physiol. 143:199-212(2007).
RN [7]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=17202255; DOI=10.1073/pnas.0610062104;
RA Philippar K., Geis T., Ilkavets I., Oster U., Schwenkert S., Meurer J.,
RA Soll J.;
RT "Chloroplast biogenesis: the use of mutants to study the etioplast-
RT chloroplast transition.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:678-683(2007).
CC -!- FUNCTION: Voltage-dependent high-conductance channel with a slight
CC cation-selectivity; selective for amino acids but excludes
CC triosephosphates or uncharged sugars (By similarity). Non-essential
CC amino acid-selective channel protein and translocation pore for
CC NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB.
CC {ECO:0000250, ECO:0000269|PubMed:17202255}.
CC -!- SUBUNIT: Homodimer and oligomers in membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast outer membrane
CC {ECO:0000269|PubMed:17098851}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17098851}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. Plastid outer
CC envelope porin OEP16 (TC 1.B.30) subfamily. {ECO:0000305}.
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DR EMBL; AL162651; CAB83138.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80405.1; -; Genomic_DNA.
DR EMBL; AK117583; BAC42241.1; -; mRNA.
DR EMBL; BT005150; AAO50683.1; -; mRNA.
DR PIR; T48077; T48077.
DR RefSeq; NP_191847.1; NM_116153.5.
DR AlphaFoldDB; Q9LZH8; -.
DR SMR; Q9LZH8; -.
DR STRING; 3702.AT3G62880.2; -.
DR TCDB; 1.B.30.2.1; the plastid outer envelope porin of 16 kda (oep16) family.
DR PaxDb; Q9LZH8; -.
DR PRIDE; Q9LZH8; -.
DR ProteomicsDB; 249365; -.
DR EnsemblPlants; AT3G62880.1; AT3G62880.1; AT3G62880.
DR GeneID; 825463; -.
DR Gramene; AT3G62880.1; AT3G62880.1; AT3G62880.
DR KEGG; ath:AT3G62880; -.
DR Araport; AT3G62880; -.
DR TAIR; locus:2081615; AT3G62880.
DR eggNOG; ENOG502S1KR; Eukaryota.
DR HOGENOM; CLU_126263_0_0_1; -.
DR InParanoid; Q9LZH8; -.
DR OMA; VFSITRC; -.
DR OrthoDB; 1544601at2759; -.
DR PhylomeDB; Q9LZH8; -.
DR PRO; PR:Q9LZH8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LZH8; baseline and differential.
DR Genevisible; Q9LZH8; AT.
DR GO; GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009527; C:plastid outer membrane; ISS:TAIR.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0042721; C:TIM22 mitochondrial import inner membrane insertion complex; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR InterPro; IPR039175; TIM22.
DR PANTHER; PTHR14110; PTHR14110; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Ion transport; Membrane; Plastid; Plastid outer membrane;
KW Porin; Reference proteome; Transmembrane; Transmembrane beta strand;
KW Transmembrane helix; Transport.
FT CHAIN 1..136
FT /note="Outer envelope pore protein 16-4, chloroplastic"
FT /id="PRO_0000415699"
FT TRANSMEM 18..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..59
FT /note="Contains 4 beta strands"
SQ SEQUENCE 136 AA; 14071 MW; 2A8E38D59790EBF7 CRC64;
MEEELLSAVP CSSLTVESVL RVATAGGLYG LCAGPRDARK IGLSGVSQAS FVAKSIGRFG
FQCGLVSGVF TMTHCGLQRY RGKNDWVNAL VGGAVAGAAV AISTRNWTQV VGMAGLVSAF
SVLANCTRTE NPNNTN
