OP1S1_DANRE
ID OP1S1_DANRE Reviewed; 336 AA.
AC Q9W6A9; Q8AYM5;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Opsin-1, short-wave-sensitive 1;
DE Short=Opsin SWS-1;
DE AltName: Full=Ultraviolet cone photoreceptor pigment;
DE AltName: Full=Ultraviolet-sensitive opsin;
GN Name=opn1sw1; Synonyms=opn1sw2, sws1, uvops;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Eye;
RX PubMed=10349976; DOI=10.1017/s0952523899163168;
RA Vihtelic T.S., Doro C.J., Hyde D.R.;
RT "Cloning and characterization of six zebrafish photoreceptor opsin cDNAs
RT and immunolocalization of their corresponding proteins.";
RL Vis. Neurosci. 16:571-585(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND BIOPHYSICOCHEMICAL
RP PROPERTIES.
RC STRAIN=AB; TISSUE=Eye;
RX PubMed=12618404; DOI=10.1093/genetics/163.2.663;
RA Chinen A., Hamaoka T., Yamada Y., Kawamura S.;
RT "Gene duplication and spectral diversification of cone visual pigments of
RT zebrafish.";
RL Genetics 163:663-675(2003).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=355 nm {ECO:0000269|PubMed:12618404};
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Retinal short single cones, outer and inner
CC segments. {ECO:0000269|PubMed:10349976}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF109373; AAD24756.1; -; mRNA.
DR EMBL; AB087810; BAC24134.1; -; Genomic_DNA.
DR RefSeq; NP_571394.1; NM_131319.1.
DR AlphaFoldDB; Q9W6A9; -.
DR SMR; Q9W6A9; -.
DR STRING; 7955.ENSDARP00000067159; -.
DR PaxDb; Q9W6A9; -.
DR GeneID; 30582; -.
DR KEGG; dre:30582; -.
DR CTD; 30582; -.
DR ZFIN; ZDB-GENE-991109-25; opn1sw1.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9W6A9; -.
DR OrthoDB; 940057at2759; -.
DR PhylomeDB; Q9W6A9; -.
DR Reactome; R-DRE-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Reactome; R-DRE-419771; Opsins.
DR PRO; PR:Q9W6A9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; NAS:UniProtKB.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001521; Opsin_blue.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00574; OPSINBLUE.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..336
FT /note="Opsin-1, short-wave-sensitive 1"
FT /id="PRO_0000197805"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 30..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 67..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..106
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 107..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 146..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..195
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 196..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 246..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..277
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 278..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT MOD_RES 289
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 88
FT /note="F -> S (in Ref. 1; AAD24756)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="F -> S (in Ref. 1; AAD24756)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="A -> S (in Ref. 1; AAD24756)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="C -> S (in Ref. 1; AAD24756)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 37268 MW; 0D6F7D4ADD616293 CRC64;
MDAWAVQFGN ASKVSPFEGE QYHIAPKWAF YLQAAFMGFV FIVGTPMNGI VLFVTMKYKK
LRQPLNYILV NISLAGFIFD TFSVSQVFVC AARGYYFLGY TLCAMEAAMG SIAGLVTGWS
LAVLAFERYV VICKPFGSFK FGQGQAVGAV VFTWIIGTAC ATPPFFGWSR YIPEGLGTAC
GPDWYTKSEE YNSESYTYFL LITCFMMPMT IIIFSYSQLL GALRAVAAQQ AESESTQKAE
REVSRMVVVM VGSFVLCYAP YAVTAMYFAN SDEPNKDYRL VAIPAFFSKS SCVYNPLIYA
FMNKQFNACI METVFGKKID ESSEVSSKTE TSSVSA
