OP24A_ARATH
ID OP24A_ARATH Reviewed; 213 AA.
AC Q1H5C9; A8MR28; Q8GX28; Q9MAJ2;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Outer envelope pore protein 24A, chloroplastic;
DE AltName: Full=Chloroplastic outer envelope pore protein of 24 kDa A;
GN Name=OEP24A; OrderedLocusNames=At1g45170; ORFNames=F27F5.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-213 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP TOPOLOGY, AND GENE FAMILY.
RX PubMed=12649433; DOI=10.1110/ps.0237503;
RA Schleiff E., Eichacker L.A., Eckart K., Becker T., Mirus O., Stahl T.,
RA Soll J.;
RT "Prediction of the plant beta-barrel proteome: a case study of the
RT chloroplast outer envelope.";
RL Protein Sci. 12:748-759(2003).
CC -!- FUNCTION: High-conductance voltage-dependent solute channel with a
CC slight selectivity for cations transporting triosephosphates,
CC dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and
CC positively or negatively charged amino acids. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomers form large rather nonselective pores in
CC plastidial outer membranes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, etioplast membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Plastid, chloroplast outer
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC Note=Present in non-green root plastids. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1H5C9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1H5C9-2; Sequence=VSP_042274;
CC -!- SIMILARITY: Belongs to the plastid outer envelope porin OEP24 (TC
CC 1.B.28) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF69166.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC43078.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC007915; AAF69166.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE32089.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32090.1; -; Genomic_DNA.
DR EMBL; BT025535; ABF58953.1; -; mRNA.
DR EMBL; AK118473; BAC43078.1; ALT_INIT; mRNA.
DR PIR; A96510; A96510.
DR RefSeq; NP_001077680.1; NM_001084211.1. [Q1H5C9-2]
DR RefSeq; NP_175131.3; NM_103591.4. [Q1H5C9-1]
DR AlphaFoldDB; Q1H5C9; -.
DR BioGRID; 26310; 2.
DR IntAct; Q1H5C9; 2.
DR STRING; 3702.AT1G45170.1; -.
DR TCDB; 1.B.28.1.4; the plastid outer envelope porin of 24 kda (oep24) family.
DR PaxDb; Q1H5C9; -.
DR PRIDE; Q1H5C9; -.
DR ProteomicsDB; 249366; -. [Q1H5C9-1]
DR DNASU; 841085; -.
DR EnsemblPlants; AT1G45170.1; AT1G45170.1; AT1G45170. [Q1H5C9-1]
DR EnsemblPlants; AT1G45170.2; AT1G45170.2; AT1G45170. [Q1H5C9-2]
DR GeneID; 841085; -.
DR Gramene; AT1G45170.1; AT1G45170.1; AT1G45170. [Q1H5C9-1]
DR Gramene; AT1G45170.2; AT1G45170.2; AT1G45170. [Q1H5C9-2]
DR KEGG; ath:AT1G45170; -.
DR Araport; AT1G45170; -.
DR TAIR; locus:2028210; AT1G45170.
DR eggNOG; ENOG502QUHD; Eukaryota.
DR InParanoid; Q1H5C9; -.
DR OMA; MTDATFI; -.
DR OrthoDB; 1227223at2759; -.
DR PhylomeDB; Q1H5C9; -.
DR PRO; PR:Q1H5C9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1H5C9; baseline and differential.
DR Genevisible; Q1H5C9; AT.
DR GO; GO:0034426; C:etioplast membrane; ISS:UniProtKB.
DR GO; GO:0031359; C:integral component of chloroplast outer membrane; ISS:UniProtKB.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0046930; C:pore complex; ISS:UniProtKB.
DR GO; GO:0015288; F:porin activity; ISS:UniProtKB.
DR GO; GO:0022843; F:voltage-gated cation channel activity; ISS:UniProtKB.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; ISS:UniProtKB.
DR InterPro; IPR034626; OEP24.
DR PANTHER; PTHR35284; PTHR35284; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chloroplast; Ion transport; Membrane; Plastid;
KW Plastid outer membrane; Porin; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..213
FT /note="Outer envelope pore protein 24A, chloroplastic"
FT /id="PRO_0000415536"
FT TOPO_DOM 1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..12
FT /note="Beta stranded; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 13..17
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..27
FT /note="Beta stranded; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..41
FT /note="Beta stranded; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..54
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..63
FT /note="Beta stranded; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..79
FT /note="Beta stranded; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..92
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..102
FT /note="Beta stranded; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..117
FT /note="Beta stranded; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..121
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..131
FT /note="Beta stranded; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..155
FT /note="Beta stranded; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..158
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..167
FT /note="Beta stranded; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..178
FT /note="Beta stranded; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..201
FT /note="Chloroplast intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..211
FT /note="Beta stranded; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 117..162
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042274"
SQ SEQUENCE 213 AA; 23591 MW; 693B6E72D8F362D0 CRC64;
MMKASFKGKF DVDKSGSVAS LTFNAGNAKL RATMTDASFV AGPSFNGLSL AVEKPGFFII
DYNVPKKDVR FQFMNTIRIA EKPLNLTYIH MRGDNRTIVD GSFVIDPANK LSANYMVGTK
NCKLKYTYVH GGIATFEPCY DVAKNMWDFA ISHKLYGGDN LKATYQTSSK MLGLEWSNNS
KSTGSFKVCA SMNLAEELKP PKLTAETTWN LEL
