ID   OPA65_NEIGO             Reviewed;         234 AA.
AC   Q04885;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Opacity protein opA65;
DE   Flags: Precursor; Fragment;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VP1;
RX   PubMed=8440254; DOI=10.1002/j.1460-2075.1993.tb05697.x;
RA   Kupsch E.-M., Knepper B., Kuroki T., Heuer I., Meyer T.F.;
RT   "Variable opacity (Opa) outer membrane proteins account for the cell
RT   tropisms displayed by Neisseria gonorrhoeae for human leukocytes and
RT   epithelial cells.";
RL   EMBO J. 12:641-650(1993).
CC   -!- FUNCTION: Implicated in a number of adherence functions. OPA proteins
CC       are implicated in pathogenesis and are subject to phase variation.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the opacity porin family. {ECO:0000305}.
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DR   EMBL; Z18940; CAA79373.1; -; Genomic_DNA.
DR   PIR; S36348; S36348.
DR   AlphaFoldDB; Q04885; -.
DR   SMR; Q04885; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   GO; GO:0009279; C:cell outer membrane; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:InterPro.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR003394; Porin_opacity.
DR   Pfam; PF02462; Opacity; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          <1..1
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..>234
FT                   /note="Opacity protein opA65"
FT                   /id="PRO_0000021901"
FT   REGION          154..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         234
SQ   SEQUENCE   234 AA;  26242 MW;  D66A0BAA8424C2F1 CRC64;
     ASKGNGRGPY VQADLAYAAE RITHDYPEPT GAKKAQLSTV SDYFRNIRTH SIHPRVSVGY
     DFGGWRIAAD YARYRKWKES NSSIKKVTED IKDNYKETKT EHQENGTFHA VSSLGLSTIY
     DFQISDKIKP YIGVRVGYGH VRHQVRSVGQ ETITVTPKPK NGTQGGPVKS TSPIPAYHEN
     RSSRRLGFGA MAGVGIDVAP GLTLDAGYRY HYWGRLENTR FKTHEASLGV RYRF