ID   OPAD_NEIGO              Reviewed;         243 AA.
AC   Q04883;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Opacity protein opA59;
DE   Flags: Precursor; Fragment;
GN   Name=opaD;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11 / F3;
RX   PubMed=8440254; DOI=10.1002/j.1460-2075.1993.tb05697.x;
RA   Kupsch E.-M., Knepper B., Kuroki T., Heuer I., Meyer T.F.;
RT   "Variable opacity (Opa) outer membrane proteins account for the cell
RT   tropisms displayed by Neisseria gonorrhoeae for human leukocytes and
RT   epithelial cells.";
RL   EMBO J. 12:641-650(1993).
CC   -!- FUNCTION: Implicated in a number of adherence functions. OPA proteins
CC       are implicated in pathogenesis and are subject to phase variation.
CC   -!- INTERACTION:
CC       Q04883; P13688: CEACAM1; Xeno; NbExp=2; IntAct=EBI-26495131, EBI-4314481;
CC       Q04883; P40198: CEACAM3; Xeno; NbExp=2; IntAct=EBI-26495131, EBI-12851752;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the opacity porin family. {ECO:0000305}.
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DR   EMBL; Z18938; CAA79371.1; -; Genomic_DNA.
DR   PIR; S36346; S36346.
DR   AlphaFoldDB; Q04883; -.
DR   SMR; Q04883; -.
DR   IntAct; Q04883; 2.
DR   MINT; Q04883; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   GO; GO:0009279; C:cell outer membrane; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:InterPro.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR003394; Porin_opacity.
DR   Pfam; PF02462; Opacity; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          <1..1
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..>243
FT                   /note="Opacity protein opA59"
FT                   /id="PRO_0000021908"
FT   NON_TER         1
FT   NON_TER         243
SQ   SEQUENCE   243 AA;  27414 MW;  5930C73917436041 CRC64;
     AGEDHGRGPY VQADLAYAYE HITHDYPEPT GTKKDKISTV SDYFRNIRTH SIHPRVSVGY
     DFGGWRIAAD YARYRKWNNN KYSVNIKELL RNDNANSGGS HLNIKTRKTE HRENGTFHAA
     SSLGLSAVYD FDTGSRFKPY IGMRVAYGHV RHQVRSVQQE TIAVTTYPQN AASSVTTNAP
     IRKLPHHESR SISSLGFGAV AGVGIDITPN LTLDAGYRYH NWGRLENTRF KTHEASLGVR
     YRF