ID   OPAG_NEIGO              Reviewed;         247 AA.
AC   Q04875;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Opacity protein opA52;
DE   AltName: Full=opA31;
DE   Flags: Precursor; Fragment;
GN   Name=opaG;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11 / F3;
RX   PubMed=8440254; DOI=10.1002/j.1460-2075.1993.tb05697.x;
RA   Kupsch E.-M., Knepper B., Kuroki T., Heuer I., Meyer T.F.;
RT   "Variable opacity (Opa) outer membrane proteins account for the cell
RT   tropisms displayed by Neisseria gonorrhoeae for human leukocytes and
RT   epithelial cells.";
RL   EMBO J. 12:641-650(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-232.
RC   STRAIN=MS11 / V18;
RX   PubMed=1815562; DOI=10.1111/j.1365-2958.1991.tb00813.x;
RA   Bhat K.S., Gibbs C.P., Barrera O., Morrison S.G., Jaehnig F., Stern A.,
RA   Kupsch E.-M., Meyer T.F., Swanson J.;
RT   "The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a
RT   family of 11 complete genes.";
RL   Mol. Microbiol. 5:1889-1901(1991).
RN   [3]
RP   ERRATUM OF PUBMED:1815562.
RX   PubMed=1584024; DOI=10.1111/j.1365-2958.1992.tb02172.x;
RA   Bhat K.S., Gibbs C.P., Barrera O., Morrison S.G., Jaehnig F., Stern S.,
RA   Kupsch E.-M., Meyer T.F., Swanson J.;
RL   Mol. Microbiol. 6:1073-1076(1992).
CC   -!- FUNCTION: Implicated in a number of adherence functions. OPA proteins
CC       are implicated in pathogenesis and are subject to phase variation.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the opacity porin family. {ECO:0000305}.
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DR   EMBL; Z18929; CAA79362.1; -; Genomic_DNA.
DR   EMBL; X60710; CAA43120.1; -; Genomic_DNA.
DR   PIR; S36330; S28627.
DR   AlphaFoldDB; Q04875; -.
DR   SMR; Q04875; -.
DR   PRIDE; Q04875; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   GO; GO:0009279; C:cell outer membrane; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:InterPro.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR003394; Porin_opacity.
DR   Pfam; PF02462; Opacity; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          <1..1
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..>247
FT                   /note="Opacity protein opA52"
FT                   /id="PRO_0000021911"
FT   NON_TER         1
FT   NON_TER         247
SQ   SEQUENCE   247 AA;  28117 MW;  4433E8505BC2C629 CRC64;
     AGEDHGRGPY VQADLAYAYE HITRDYPDAA GANKGKISTV SDYFRNIRTH SIHPRVSVGY
     DFGGWRIAAD YARYRKWHNN KYSVNIKELE RKNNKTSGGD QLNIKYQKTE HQENGTFHAV
     SSLGLSTVYD FRVNDKFKPY IGVRVGYGHV RHGIDSTKKT KNTLTAYHGA GTKPTYYDDI
     DSGKNQKNTY RQNRSSRRLG FGAMAGVGID VAPGLTLDAG YRYHYWGRLE NTRFKTHEAS
     LGVRYRF