ID   OPAJ_NEIGO              Reviewed;         260 AA.
AC   Q04882;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Opacity protein opA58;
DE   Flags: Precursor;
GN   Name=opaJ;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11;
RX   PubMed=1815562; DOI=10.1111/j.1365-2958.1991.tb00813.x;
RA   Bhat K.S., Gibbs C.P., Barrera O., Morrison S.G., Jaehnig F., Stern A.,
RA   Kupsch E.-M., Meyer T.F., Swanson J.;
RT   "The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a
RT   family of 11 complete genes.";
RL   Mol. Microbiol. 5:1889-1901(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-260.
RC   STRAIN=MS11 / F3;
RX   PubMed=8440254; DOI=10.1002/j.1460-2075.1993.tb05697.x;
RA   Kupsch E.-M., Knepper B., Kuroki T., Heuer I., Meyer T.F.;
RT   "Variable opacity (Opa) outer membrane proteins account for the cell
RT   tropisms displayed by Neisseria gonorrhoeae for human leukocytes and
RT   epithelial cells.";
RL   EMBO J. 12:641-650(1993).
CC   -!- FUNCTION: Implicated in a number of adherence functions. OPA proteins
CC       are implicated in pathogenesis and are subject to phase variation.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the opacity porin family. {ECO:0000305}.
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DR   EMBL; X52371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z18937; CAA79370.1; -; Genomic_DNA.
DR   PIR; S16611; S16611.
DR   AlphaFoldDB; Q04882; -.
DR   SMR; Q04882; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   GO; GO:0009279; C:cell outer membrane; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:InterPro.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR016373; Opacity.
DR   InterPro; IPR003394; Porin_opacity.
DR   Pfam; PF02462; Opacity; 1.
DR   PIRSF; PIRSF002984; Opacity; 1.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..260
FT                   /note="Opacity protein opA58"
FT                   /id="PRO_0000021914"
SQ   SEQUENCE   260 AA;  29243 MW;  EBF5BDCED52ECE43 CRC64;
     MNPAPKKPSL LFSSLLFSSA AQAAGEDHGR GPYVQADLAY AYEHITHDYP EQTDPSKGKI
     STVSDYFRNI RTHSIHPRVS VGYDFGGWRI AADYARYRKW NNNKYSVSIK ELLRNKVNGN
     RTDRKTENQE NGTFHAVSSL GLSAVYDFKL NDKFKPYIGA RVAYGHVRHS IDSTKKTTEV
     TTILHGPGTT PTVYPGKNTQ DAHRESDSIR RVGLGAVAGV GIDITPNLTL DAGYRYHYWG
     RLENTRFKTH EASLGVRYRF