ID   OPALI_BOVIN             Reviewed;         142 AA.
AC   Q5E9I3;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Opalin;
DE   AltName: Full=Oligodendrocytic myelin paranodal and inner loop protein;
DE   AltName: Full=Transmembrane protein 10;
GN   Name=OPALIN; Synonyms=TMEM10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Central nervous system-specific myelin protein that increase
CC       myelin genes expression during oligodendrocyte differentiation.
CC       Promotes oligodendrocyte terminal differentiation.
CC       {ECO:0000250|UniProtKB:Q7M750}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M750};
CC       Single-pass type I membrane protein {ECO:0000255}. Note=In the CNS,
CC       enriched in the myelin paranodal and inner loop membranes, but not that
CC       of the PNS. Enriched in the leading edge of extending processes.
CC       {ECO:0000250|UniProtKB:Q7M750}.
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DR   EMBL; BT020937; AAX08954.1; -; mRNA.
DR   AlphaFoldDB; Q5E9I3; -.
DR   InParanoid; Q5E9I3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0044291; C:cell-cell contact zone; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   InterPro; IPR026609; Opalin.
DR   PANTHER; PTHR21102; PTHR21102; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..142
FT                   /note="Opalin"
FT                   /id="PRO_0000072590"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          78..94
FT                   /note="Required for plasma membrane localization"
FT                   /evidence="ECO:0000250|UniProtKB:Q7M750"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  15771 MW;  FEF979931F237B8D CRC64;
     MSFSLNFTLP ANTTSSPVVT SGKGADCGPS LGLAAGIPSL VATALLVALL LILIHRRRRS
     SESTEEIERP CEISEIYDNP RVAENPRRSP THEKNIMGAE EAHIYVKTVS GSQEPMRDTY
     RPAVEMERRR GLWWLIPRLS LE