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OPALI_PIG
ID   OPALI_PIG               Reviewed;         142 AA.
AC   Q29102;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Opalin;
DE   AltName: Full=Oligodendrocytic myelin paranodal and inner loop protein;
DE   AltName: Full=Transmembrane protein 10;
DE   AltName: Full=Transmembrane protein sp83.5;
GN   Name=OPALIN; Synonyms=SP83.5, TMEM10;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ALTERNATIVE SPLICING, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Brain;
RX   PubMed=9746342; DOI=10.1046/j.1432-1327.1998.2560024.x;
RA   Bangsow T., Schepelmann S., Martin C., May M., Oberthuer A., Perl S.,
RA   Knuepfer E., Zinke H., Gassen H.G.;
RT   "Identification of a gene selectively expressed in the brain, which encodes
RT   a putative transmembrane protein and a soluble cytoplasmic isoform.";
RL   Eur. J. Biochem. 256:24-35(1998).
CC   -!- FUNCTION: Central nervous system-specific myelin protein that increase
CC       myelin genes expression during oligodendrocyte differentiation.
CC       Promotes oligodendrocyte terminal differentiation.
CC       {ECO:0000250|UniProtKB:Q7M750}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm
CC       {ECO:0000269|PubMed:9746342}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane
CC       {ECO:0000250|UniProtKB:Q7M750}; Single-pass type I membrane protein
CC       {ECO:0000255}. Note=In the CNS, enriched in the myelin paranodal and
CC       inner loop membranes, but not that of the PNS. Enriched in the leading
CC       edge of extending processes. {ECO:0000250|UniProtKB:Q7M750}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q29102-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q29102-2; Sequence=VSP_003990;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in brain.
CC       {ECO:0000269|PubMed:9746342}.
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DR   EMBL; X89480; CAA61669.1; -; mRNA.
DR   EMBL; Y11026; CAA71910.1; -; mRNA.
DR   PIR; S58082; S58082.
DR   RefSeq; NP_999375.1; NM_214210.1. [Q29102-1]
DR   AlphaFoldDB; Q29102; -.
DR   STRING; 9823.ENSSSCP00000011194; -.
DR   PaxDb; Q29102; -.
DR   PRIDE; Q29102; -.
DR   Ensembl; ENSSSCT00005074446; ENSSSCP00005046767; ENSSSCG00005045976. [Q29102-1]
DR   GeneID; 397416; -.
DR   KEGG; ssc:397416; -.
DR   CTD; 93377; -.
DR   eggNOG; ENOG502RWAT; Eukaryota.
DR   HOGENOM; CLU_1824653_0_0_1; -.
DR   InParanoid; Q29102; -.
DR   TreeFam; TF337818; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q29102; SS.
DR   GO; GO:0044291; C:cell-cell contact zone; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   InterPro; IPR026609; Opalin.
DR   PANTHER; PTHR21102; PTHR21102; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Cytoplasm; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..142
FT                   /note="Opalin"
FT                   /id="PRO_0000072593"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          78..94
FT                   /note="Required for plasma membrane localization"
FT                   /evidence="ECO:0000250|UniProtKB:Q7M750"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..96
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003990"
SQ   SEQUENCE   142 AA;  15771 MW;  FEF979931F237B8D CRC64;
     MSFSLNFTLP ANTTSSPVVT SGKGADCGPS LGLAAGIPSL VATALLVALL LILIHRRRRS
     SESTEEIERP CEISEIYDNP RVAENPRRSP THEKNIMGAE EAHIYVKTVS GSQEPMRDTY
     RPAVEMERRR GLWWLIPRLS LE
 
 
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