ID   OPALI_PONAB             Reviewed;         141 AA.
AC   Q5R461;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Opalin;
DE   AltName: Full=Oligodendrocytic myelin paranodal and inner loop protein;
DE   AltName: Full=Transmembrane protein 10;
GN   Name=OPALIN; Synonyms=TMEM10;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Central nervous system-specific myelin protein that increase
CC       myelin genes expression during oligodendrocyte differentiation.
CC       Promotes oligodendrocyte terminal differentiation.
CC       {ECO:0000250|UniProtKB:Q7M750}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M750};
CC       Single-pass type I membrane protein {ECO:0000255}. Note=In the CNS,
CC       enriched in the myelin paranodal and inner loop membranes, but not that
CC       of the PNS. Enriched in the leading edge of extending processes.
CC       {ECO:0000250|UniProtKB:Q7M750}.
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DR   EMBL; CR861397; CAH93455.1; -; mRNA.
DR   RefSeq; NP_001127023.1; NM_001133551.1.
DR   AlphaFoldDB; Q5R461; -.
DR   STRING; 9601.ENSPPYP00000002923; -.
DR   Ensembl; ENSPPYT00000036631; ENSPPYP00000035729; ENSPPYG00000002519.
DR   GeneID; 100174048; -.
DR   KEGG; pon:100174048; -.
DR   CTD; 93377; -.
DR   eggNOG; ENOG502RWAT; Eukaryota.
DR   GeneTree; ENSGT00390000009395; -.
DR   InParanoid; Q5R461; -.
DR   OrthoDB; 1457772at2759; -.
DR   Proteomes; UP000001595; Chromosome 10.
DR   GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   InterPro; IPR026609; Opalin.
DR   PANTHER; PTHR21102; PTHR21102; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Opalin"
FT                   /id="PRO_0000072594"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          61..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          77..93
FT                   /note="Required for plasma membrane localization"
FT                   /evidence="ECO:0000250|UniProtKB:Q7M750"
FT   COMPBIAS        61..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   141 AA;  15602 MW;  76BA42D79EF9088B CRC64;
     MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPSLV ATALLVALLF TLIHRRRSSI
     EAMEESDRPC EISEIDDSPK ISENPRRSPT HEKNTMGAQE AHIYVKTAAG SEEPVHDRYR
     PTIEMERRRG LWWLVPRLSL E