ID   ARX1_ASHGO              Reviewed;         591 AA.
AC   Q74ZU6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=AGR102C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54592.1; -; Genomic_DNA.
DR   RefSeq; NP_986768.1; NM_211830.1.
DR   AlphaFoldDB; Q74ZU6; -.
DR   SMR; Q74ZU6; -.
DR   STRING; 33169.AAS54592; -.
DR   PRIDE; Q74ZU6; -.
DR   EnsemblFungi; AAS54592; AAS54592; AGOS_AGR102C.
DR   GeneID; 4623070; -.
DR   KEGG; ago:AGOS_AGR102C; -.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q74ZU6; -.
DR   OMA; KPSWVHS; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..591
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148992"
SQ   SEQUENCE   591 AA;  64096 MW;  B9B5BC6F7EA59113 CRC64;
     MALAISSEDT QVLLKDKNVL HESNVDKYRT AGQITQTALR FLAGLINDSY HHRTRATPLS
     VAELCMLTDS FVERCVRQAF ANKANERGIA HPTTIDVDEI TQGWAPETDD AANMERWNRD
     RQANSGSCQG ARSAISGFLH EGDVVKLTVG CHIDGYTAQV SHTMVVYPTT RREADQALVP
     AGPLLGAKAD AVAAATIAKE SVTSLLACAQ ATEKLPAAFG ERQVTGTLIR RVVDAVARSY
     NCAVVPGSRV RRVRRFLAGQ NEGVVAERDI KGVHWTEAHQ EAALLASSVE TTDVTRVDAS
     NKSANDSAVA TDDFVVVSGE AYLIDLKIAP LKDLPRGLLT LQTVDHFSGK SHRKDELLAR
     ASLICRDFAK QHVLKLKSSR QLLHKLDSKG VYPTKLAHLT AAFPLDPESP DWDAVSKELK
     HLRLGLAEVT NNYLANEKPV QLCRLVPWDV ILKAVNPTGK HGTDASNPTL PGYEIPLPQL
     GISSLRLKSL LKDSLPVPVA RESITVLLCP AEVTSTGSPE LLKLTGGPTT TPSWIHSDYE
     LNVSDPVVQG ILQLAELSKD KRFGLAIRET QPWKQKIPSA AAVTSADVEM A