ID   OPDE_PSEAE              Reviewed;         402 AA.
AC   Q01602;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Transcription regulatory protein OpdE;
GN   Name=opdE; OrderedLocusNames=PA2219;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / H103;
RX   PubMed=1427017; DOI=10.1016/0378-1097(92)90347-q;
RA   Huang H., Siehnel R.J., Bellido F., Rawling E., Hancock R.E.W.;
RT   "Analysis of two gene regions involved in the expression of the imipenem-
RT   specific, outer membrane porin protein OprD of Pseudomonas aeruginosa.";
RL   FEMS Microbiol. Lett. 76:267-274(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Regulates the expression of oprD which encodes the imipenem-
CC       specific porin.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To B.subtilis YwfA. {ECO:0000305}.
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DR   EMBL; Z14064; CAA78446.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG05607.1; -; Genomic_DNA.
DR   PIR; S23860; S23860.
DR   RefSeq; NP_250909.1; NC_002516.2.
DR   RefSeq; WP_003113706.1; NZ_QZGE01000014.1.
DR   AlphaFoldDB; Q01602; -.
DR   SMR; Q01602; -.
DR   STRING; 208964.PA2219; -.
DR   PaxDb; Q01602; -.
DR   EnsemblBacteria; AAG05607; AAG05607; PA2219.
DR   GeneID; 878599; -.
DR   KEGG; pae:PA2219; -.
DR   PATRIC; fig|208964.12.peg.2323; -.
DR   PseudoCAP; PA2219; -.
DR   HOGENOM; CLU_001265_61_1_6; -.
DR   InParanoid; Q01602; -.
DR   OMA; MGQFTLF; -.
DR   PhylomeDB; Q01602; -.
DR   BioCyc; PAER208964:G1FZ6-2259-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..402
FT                   /note="Transcription regulatory protein OpdE"
FT                   /id="PRO_0000058060"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  41592 MW;  0C5701C4AD2FDE16 CRC64;
     MTTRALDTAN ENPEQSGSWS GVLAIAVCAF ALVASEFLPV SLLTPIANDL GTTEGMAGQG
     IAISGAFAVL TSLFISSVAG SLNRKTLLLG LTAAMGMSGA IVALAPNYFV YMLGRALIGI
     VIGGFWSMSA ATAMRLVPAN DVPRALALVN GGNALATVVA APLGAWLGTL IGWRGAFLCL
     VPVALVALAW QWTTLPSMRA GARAPGPGNV FTVFALLKRP GVMLGMLASS LFFMGQFSLF
     TYVRPFLETV TGVHGAHVSL VLLVIGAAGF IGTLLIDRVL QRRFFQTLVA IPLLMALIAL
     VLTVLGGWPA IVVVLLGLWG LTGTSAPVGW WAWIARVFPE DAEAGGGLFV AVVQLSIALG
     STLGGLLFDR TGYQATFFAS AAMLLIAAFL TILTARSKAP AG