ID   ARX1_CANAL              Reviewed;         564 AA.
AC   Q5AI37; A0A1D8PCY6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=CAALFM_C103230CA;
GN   ORFNames=CaO19.10533, CaO19.3015;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26004.1; -; Genomic_DNA.
DR   RefSeq; XP_721513.1; XM_716420.1.
DR   AlphaFoldDB; Q5AI37; -.
DR   SMR; Q5AI37; -.
DR   STRING; 237561.Q5AI37; -.
DR   PRIDE; Q5AI37; -.
DR   GeneID; 3636811; -.
DR   KEGG; cal:CAALFM_C103230CA; -.
DR   CGD; CAL0000194302; ARX1.
DR   VEuPathDB; FungiDB:C1_03230C_A; -.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q5AI37; -.
DR   OMA; KPSWVHS; -.
DR   OrthoDB; 834026at2759; -.
DR   PRO; PR:Q5AI37; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..564
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148993"
SQ   SEQUENCE   564 AA;  62233 MW;  1B95FF8831F0CCA8 CRC64;
     MQLAVRQEDA DILLKQKNVL DELVVEKYRV AGQITQTALA YITSLINNSY HLQTSPKLTI
     QQLCLLTDSF LLKLLSRQYV NKVNEKGIAH PTTINVNQLL NGFSPEIDDE REFFLNQGDV
     VTISLGVHID GYTSQVSHTL VIYPPSADAK PEGPLLGSNA DALCACHLAT ESVVVLLGCS
     LSPEKLPANL KNVSNTVTGS QIRELVDAIA DSFNCVVVPG SKIRRVRRFL AGQAEGIVAE
     RDFKGVVWDE SHQEARLLKQ SNNTSTDLIL SDSNKPVQTN NSSAIPTDDF VVVPGEVYQI
     DIRMTGLSDV NEIGIVTTEE IDHFTGKNNK QDFNAKSSIF IRDFAVTHQL KLKTSKKLLG
     EIDRQFSVYP FKLDYASKNF PINTESSEDE IKQQIAAIGQ DMKSNRLGAA ELSNRHLIQP
     KPIQTTKFIP LKEILLSANP TGKHGIDATK PVLPGMEIPL PNLGVSSLKL KSLLKTGRSI
     NNVRESTTVA INENNQELIR LTGGEATAKS NWVHSQYKLP ASLNETIGQL VQISKDKRFG
     IKIKEVVPYK VQQSNMSVES MQID