ID   ARX1_CANGA              Reviewed;         588 AA.
AC   Q6FL44;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=CAGL0L06314g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG62020.1; -; Genomic_DNA.
DR   RefSeq; XP_449050.1; XM_449050.1.
DR   AlphaFoldDB; Q6FL44; -.
DR   SMR; Q6FL44; -.
DR   STRING; 5478.XP_449050.1; -.
DR   PRIDE; Q6FL44; -.
DR   EnsemblFungi; CAG62020; CAG62020; CAGL0L06314g.
DR   GeneID; 2890758; -.
DR   KEGG; cgr:CAGL0L06314g; -.
DR   CGD; CAL0135380; CAGL0L06314g.
DR   VEuPathDB; FungiDB:CAGL0L06314g; -.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q6FL44; -.
DR   OMA; KPSWVHS; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..588
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148994"
SQ   SEQUENCE   588 AA;  64730 MW;  A91E7B8CAF9F74BC CRC64;
     MDLAVSNEDS QILLKDKNVL QETVLDKYRT SGQITQTALK FVTDLINDVY HYKKVQTPLS
     ISELCLMADS FIVNRLEQYY KHKVNERGIA LPTMIDVDAV ASGWCPEVDD TENIKKWNNN
     SDETSPFASS ITGYLRHGDV VKISLGCHID GYTSQVTHTM VIYPTDETNT KPTGPLLGSK
     ADAVAASHIA SESVTALLAC SLTPEKLPQS LRNANTNSVT GHQIRSVVDT IAKAYNCAVV
     PGSRVRRIRR FLAGQNEGIV AEKDYKGVVW TEAHQEANLL ANTEVQDIVV ANNQNKLVAS
     SAIPSDDFSV DVGEVYLIDL KFCPLTDCQK KGLITLETVD SYTGKSHKKN QLIARSGAYV
     RDYAQSYTLK LKTARQLLTK IDKNGVYPLK LSHLSTDFPL TEFTAEESDA VKKDLRSFRL
     GMNEITNNFL CVETPIQVAK WVPWDHILNS TNKNGALSYD ASAALTLPGH EIPLPKLGIS
     GIKLKSLMNS TNEVMTLPVA RECSTVILCG SDVSVSGKPE LFRLTGGSKT AQPSWVHSAR
     ELNPADPVVQ GIFNLAELSK DKRFGLTMRE TQPMKKNINL ASDTTMEM