ID   ARX1_DEBHA              Reviewed;         564 AA.
AC   Q6BI90;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=DEHA2G12562g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90567.2; -; Genomic_DNA.
DR   RefSeq; XP_462081.2; XM_462081.1.
DR   AlphaFoldDB; Q6BI90; -.
DR   SMR; Q6BI90; -.
DR   STRING; 4959.XP_462081.2; -.
DR   EnsemblFungi; CAG90567; CAG90567; DEHA2G12562g.
DR   GeneID; 2904993; -.
DR   KEGG; dha:DEHA2G12562g; -.
DR   VEuPathDB; FungiDB:DEHA2G12562g; -.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q6BI90; -.
DR   OMA; KPSWVHS; -.
DR   OrthoDB; 834026at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..564
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148995"
SQ   SEQUENCE   564 AA;  62176 MW;  DFFD4BDF122B957E CRC64;
     MQLAVHQDDA DILLKERNQL NESILDKYRV AGQIAQTGLK YVISLINDSY HLGKTETPYT
     CQELCVMGDS MVTRLLAKVY NNDIREKGIS NPVSIELNEI VGNFAPEIDD ASKFTFNAGD
     IVTITLGVHI DGYAANVSHT VVIYPTGVTI DNELKPPGPL LGSKADSICA AHIATETVVA
     LLGMALTPEK LPTQLDPNNT KLVTGKQIRN IVNSIAESFN CTVVPGSKVR RIRRFLAGQA
     EGVVAEKDFK GVVWSESDQE ELLLNKYNKN DDQQLVLHNK QGSEFTNNSS AIPTDEFVVA
     ADEVYNVDIK MCSTSDFKEL GLVTLEEIDE FTGLNNKTNE FKTKSTIYIR DYAVNYQLRL
     KNSRSLLGKI DKEFTVFPFK LSHTSPSFPA TNSQDLATLK KELIANKLGL SELANRHLIN
     AKPIQVTKFI PFETILKTSN PTGKHGIDSN KPALPGMEIP LPHLGISSLK LKALLKNSSS
     IANARESTTV ILNSFNNANE VIRLTGGNNS APSWVHSDYS LNPQCKESVD HLLQLTKDKR
     FGIKVKECQP MKLTADAPES MQMD