ID   ARX1_KLULA              Reviewed;         571 AA.
AC   Q6CKB6; O13365;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=KLLA0F11979g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-323.
RC   STRAIN=ATCC MYA-539 / JBD100;
RX   PubMed=9884236; DOI=10.1099/00221287-144-12-3437;
RA   Zeeman A.-M., Luttik M.A.H., Thiele C., van Dijken J.P., Pronk J.T.,
RA   Steensma H.Y.;
RT   "Inactivation of the Kluyveromyces lactis KlPDA1 gene leads to loss of
RT   pyruvate dehydrogenase activity, impairs growth on glucose and triggers
RT   aerobic alcoholic fermentation.";
RL   Microbiology 144:3437-3446(1998).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98331.1; -; Genomic_DNA.
DR   EMBL; AF023920; AAD03772.1; -; Genomic_DNA.
DR   RefSeq; XP_455623.1; XM_455623.1.
DR   AlphaFoldDB; Q6CKB6; -.
DR   SMR; Q6CKB6; -.
DR   STRING; 28985.XP_455623.1; -.
DR   EnsemblFungi; CAG98331; CAG98331; KLLA0_F11979g.
DR   GeneID; 2895113; -.
DR   KEGG; kla:KLLA0_F11979g; -.
DR   eggNOG; KOG2776; Eukaryota.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q6CKB6; -.
DR   OMA; KPSWVHS; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..571
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148996"
SQ   SEQUENCE   571 AA;  63261 MW;  B54CCA51449F108E CRC64;
     MALQISKEDT QVLLKDKNVL IEPTIEKYRT AGQIAQTALN FLISLINKMY HEKSMEPLPI
     HQLCLLTDSF IADCLSTKFN NKVNEKGISM PTCIDIDEIN ENWCPEVDDI ENLSRWNQKS
     RSTKSIELCN GVTSSLSGFL KVGDVAKITL GCHIDGYTCN VSHTVVIYPT VQDAQSGKLL
     PEAALLGGKA DALAATHIAV ESVTNLLAAA NDLTKLPADF NATKVTGSLI RTVVDTIAQS
     YNCCVVPGSR IRRIKRFLSG QNENIIVERD FKGVIWTESH QEAAMLARTV NETAVDVKRK
     NPFITEDTVV PTDDFTVVKG EVYMIDLKLA PLQGLEPGLI TLHTVDQFSG KSESSDVVAR
     PGAICRDFSK SHVLKLRAAR QVLTRLDKQG VYPTKLAHIA DSFPLDVQEP DFETIKQEIK
     PFRLGLSEIS NNYLTIDRDV TIVKHVPWAK ILDLTNPSGV SSYDAMAKNK GLYPGFELPL
     PKLGLSNLQL KSLLKKHSTP VPVVRQCVTV AICDEELLRI SGNLKSNWVH SVYSMDTASN
     IVAGIFKLAQ LSEDKRFGLK IRETQPWKMK F