ID   ARX1_YARLI              Reviewed;         484 AA.
AC   Q6CCY2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable metalloprotease ARX1;
DE            EC=3.-.-.-;
DE   AltName: Full=Associated with ribosomal export complex protein 1;
GN   Name=ARX1; OrderedLocusNames=YALI0C05599g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probable metalloprotease involved in proper assembly of pre-
CC       ribosomal particles during the biogenesis of the 60S ribosomal subunit.
CC       Accompanies the pre-60S particles to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC       ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M24 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG81781.1; -; Genomic_DNA.
DR   RefSeq; XP_501480.1; XM_501480.1.
DR   AlphaFoldDB; Q6CCY2; -.
DR   SMR; Q6CCY2; -.
DR   STRING; 4952.CAG81781; -.
DR   EnsemblFungi; CAG81781; CAG81781; YALI0_C05599g.
DR   GeneID; 2910102; -.
DR   KEGG; yli:YALI0C05599g; -.
DR   VEuPathDB; FungiDB:YALI0_C05599g; -.
DR   HOGENOM; CLU_477525_0_0_1; -.
DR   InParanoid; Q6CCY2; -.
DR   OMA; LTNDACL; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   SUPFAM; SSF55920; SSF55920; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW   Reference proteome.
FT   CHAIN           1..484
FT                   /note="Probable metalloprotease ARX1"
FT                   /id="PRO_0000148998"
SQ   SEQUENCE   484 AA;  52671 MW;  9B9C9DB494B8AEB8 CRC64;
     MSLARSTALL DEKNTLTSSV TDKYRLAGKI TQTCLQHIIQ TVLTQYETYT VGEMCRMGDE
     FLERATTAVY KSVAEKGIAQ PVRIEKQEFV GGVSPENGDK FQGGMLAPGD LVKISLGVYI
     DGYTAQVTQT EVVRHVPNTS AGETEQPLTG SPADAVCASY LASEAVIAYL AQVTDPNPGK
     AVGVVTGTKI RELVEKIAAA YHVKIVPGSS VRRIRRFLAG QHDIVLERDY KGVLWEVEGE
     EERALHAVKL AESEAKQEST EGAVCLYEQH IEEEENFTVE AGEAYQVDIQ MAAAPQKGAI
     RLYDFQGYDE SGTVINQYGR DFSVTYGLKI QASRKLLSQL EATTSVYPFK LSHVESNVAK
     ARLGLGEILA HQILVPIPVK VAKFVPLAAL YEFSKNSKAR ARDEASKAVP VARNSSSVLL
     TNDACLRLTG GQAFPPPYVH SAFELPEDVT NLLKLVGHKH GAKVKDVLPG DVDMAPAKEA
     KMEE