OPGC_ECOLI
ID OPGC_ECOLI Reviewed; 385 AA.
AC P75920;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Glucans biosynthesis protein C;
DE EC=2.1.-.-;
GN Name=mdoC; Synonyms=opgC, ymdD; OrderedLocusNames=b1047, JW1034;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION.
RX PubMed=10368134; DOI=10.1128/jb.181.12.3626-3631.1999;
RA Lacroix J.-M., Lanfroy E., Cogez V., Lequette Y., Bohin A., Bohin J.-P.;
RT "The mdoC gene of Escherichia coli encodes a membrane protein that is
RT required for succinylation of osmoregulated periplasmic glucans.";
RL J. Bacteriol. 181:3626-3631(1999).
CC -!- FUNCTION: Necessary for the succinyl substitution of periplasmic
CC glucans. Could catalyze the transfer of succinyl residues from the
CC cytoplasmic side of the membrane to the nascent glucan backbones on the
CC periplasmic side of the membrane.
CC -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the acyltransferase 3 family. OpgC subfamily.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC74131.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35837.1; -; Genomic_DNA.
DR PIR; D64847; D64847.
DR RefSeq; NP_415565.1; NC_000913.3.
DR RefSeq; WP_001070375.1; NZ_SSZK01000058.1.
DR AlphaFoldDB; P75920; -.
DR BioGRID; 4260688; 280.
DR STRING; 511145.b1047; -.
DR TCDB; 9.B.97.7.1; the acyltransferase-3/putative acetyl-coa transporter (atat) family.
DR PaxDb; P75920; -.
DR PRIDE; P75920; -.
DR EnsemblBacteria; AAC74131; AAC74131; b1047.
DR EnsemblBacteria; BAA35837; BAA35837; BAA35837.
DR GeneID; 946944; -.
DR KEGG; ecj:JW1034; -.
DR KEGG; eco:b1047; -.
DR PATRIC; fig|1411691.4.peg.1222; -.
DR EchoBASE; EB3635; -.
DR eggNOG; COG1835; Bacteria.
DR HOGENOM; CLU_036182_2_0_6; -.
DR InParanoid; P75920; -.
DR OMA; YFSYMLY; -.
DR PhylomeDB; P75920; -.
DR BioCyc; EcoCyc:G6552-MON; -.
DR UniPathway; UPA00637; -.
DR PRO; PR:P75920; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; ISM:EcoCyc.
DR GO; GO:0016748; F:succinyltransferase activity; IMP:EcoCyc.
DR GO; GO:0016741; F:transferase activity, transferring one-carbon groups; IEA:UniProtKB-UniRule.
DR GO; GO:1900727; P:osmoregulated periplasmic glucan biosynthetic process; IMP:EcoCyc.
DR HAMAP; MF_01066; MdoC_OpgC; 1.
DR InterPro; IPR002656; Acyl_transf_3_dom.
DR InterPro; IPR023723; Glucans_biosynth_C.
DR Pfam; PF01757; Acyl_transf_3; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Cell membrane; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..385
FT /note="Glucans biosynthesis protein C"
FT /id="PRO_0000218049"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 385 AA; 44690 MW; 24B869CE8E0224DF CRC64;
MNPVPAQREY FLDSIRAWLM LLGIPFHISL IYSSHTWHVN SAESSLWLTL FNDFIHSFRM
QVFFVISGYF SYMLFLRYPL KKWWKVRVER VGIPMLTAIP LLTLPQFIML QYVKGKAESW
PGLSLYDKYN TLAWELISHL WFLLVLVVMT TLCVWIFKRI RNNLENSDKT NKKFSMVKLS
VIFLCLGIGY AVIRRTIFIV YPPILSNGMF NFIVMQTLFY LPFFILGALA FIFPHLKALF
TTPSRGCTLA AALAFVAYLL NQRYGSGDAW MYETESVITM VLGLWMVNVV FSFGHRLLNF
QSARVTYFVN ASLFIYLVHH PLTLFFGAYI TPHITSNWLG FLCGLIFVVG IAIILYEIHL
RIPLLKFLFS GKPVVKREND KAPAR
