ID   ARXS1_MOUSE             Reviewed;         180 AA.
AC   C0HK79; B1AUR7; Q8BK31; Q9D365; Q9D6F2;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2016, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Adipocyte-related X-chromosome expressed sequence 1 {ECO:0000303|PubMed:21177646};
GN   Name=Arxes1 {ECO:0000303|PubMed:21177646, ECO:0000312|MGI:MGI:1923469};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND INDUCTION.
RX   PubMed=21177646; DOI=10.1093/nar/gkq1289;
RA   Prokesch A., Bogner-Strauss J.G., Hackl H., Rieder D., Neuhold C.,
RA   Walenta E., Krogsdam A., Scheideler M., Papak C., Wong W.C., Vinson C.,
RA   Eisenhaber F., Trajanoski Z.;
RT   "Arxes: retrotransposed genes required for adipogenesis.";
RL   Nucleic Acids Res. 39:3224-3239(2011).
CC   -!- FUNCTION: Plays a role in adipogenesis. {ECO:0000269|PubMed:21177646}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:21177646}; Single-pass type II membrane protein
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in epididymal white and brown
CC       adipose tissue with low levels in heart. {ECO:0000269|PubMed:21177646}.
CC   -!- DEVELOPMENTAL STAGE: Strongly up-regulated during adipogenesis.
CC       {ECO:0000269|PubMed:21177646}.
CC   -!- INDUCTION: By the PPARG agonist rosiglitazone.
CC       {ECO:0000269|PubMed:21177646}.
CC   -!- MISCELLANEOUS: Arxes1 and Arxes2 appear to have arisen by
CC       retrotransposition of the signal peptidase Spcs3 followed by a
CC       segmental duplication event. {ECO:0000303|PubMed:21177646}.
CC   -!- SIMILARITY: Belongs to the SPCS3 family. {ECO:0000305}.
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DR   EMBL; AK018307; BAB31154.1; -; mRNA.
DR   EMBL; AL671914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53192.1; -.
DR   RefSeq; NP_083817.1; NM_029541.3.
DR   RefSeq; NP_084099.1; NM_029823.2.
DR   AlphaFoldDB; C0HK79; -.
DR   SMR; C0HK79; -.
DR   STRING; 10090.ENSMUSP00000051250; -.
DR   GlyGen; C0HK79; 1 site.
DR   PRIDE; C0HK79; -.
DR   DNASU; 76219; -.
DR   Ensembl; ENSMUST00000057625; ENSMUSP00000062660; ENSMUSG00000048355.
DR   Ensembl; ENSMUST00000058119; ENSMUSP00000051250; ENSMUSG00000048040.
DR   GeneID; 76219; -.
DR   GeneID; 76976; -.
DR   KEGG; mmu:76219; -.
DR   KEGG; mmu:76976; -.
DR   CTD; 76219; -.
DR   CTD; 76976; -.
DR   MGI; MGI:1923469; Arxes1.
DR   VEuPathDB; HostDB:ENSMUSG00000048040; -.
DR   VEuPathDB; HostDB:ENSMUSG00000048355; -.
DR   eggNOG; KOG3372; Eukaryota.
DR   OMA; THEREIM; -.
DR   OrthoDB; 1514162at2759; -.
DR   BioGRID-ORCS; 76219; 1 hit in 33 CRISPR screens.
DR   BioGRID-ORCS; 76976; 2 hits in 31 CRISPR screens.
DR   PRO; PR:C0HK79; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; C0HK79; protein.
DR   Bgee; ENSMUSG00000048040; Expressed in gonadal fat pad and 257 other tissues.
DR   ExpressionAtlas; C0HK79; baseline and differential.
DR   Genevisible; Q9D365; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005787; C:signal peptidase complex; IBA:GO_Central.
DR   GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
DR   GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR   GO; GO:0006465; P:signal peptide processing; IBA:GO_Central.
DR   InterPro; IPR007653; SPC3.
DR   PANTHER; PTHR12804; PTHR12804; 1.
DR   Pfam; PF04573; SPC22; 1.
DR   PIRSF; PIRSF016089; SPC22; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..180
FT                   /note="Adipocyte-related X-chromosome expressed sequence 1"
FT                   /id="PRO_0000438510"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..32
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..180
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        141
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   180 AA;  20146 MW;  7980A041F61AAFBB CRC64;
     MNSLLSRANS LFAFTLSVMA ALTLGCILTT AFKDRSAPVR LHVSRILLKK VEDFTGPRKK
     SDLGFITFHI SADLEKTFDW NVKQLFLYLS AEYSTKSNAV NQVVLWDKIL LRGENPKLNL
     KDVKSKYFFF DDGHGLKGNR NVTLTLSWQV IPIAGILPLV TGSGRVSVPF PDSYEIATTF