ARX_DANRE
ID ARX_DANRE Reviewed; 453 AA.
AC O42115;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Aristaless-related homeobox protein;
DE Short=ARX;
GN Name=arx;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=9256348; DOI=10.1016/s0925-4773(97)00062-2;
RA Miura H., Yanazawa M., Kato K., Kitamura K.;
RT "Expression of a novel aristaless related homeobox gene 'Arx' in the
RT vertebrate telencephalon, diencephalon and floor plate.";
RL Mech. Dev. 65:99-109(1997).
CC -!- FUNCTION: Appears to be indispensable for the central nervous system
CC development. May have a role in the neuronal differentiation of the
CC ganglionic eminence and ventral thalamus. May also be involved in
CC axonal guidance in the floor plate.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- TISSUE SPECIFICITY: Expressed in brain.
CC -!- DEVELOPMENTAL STAGE: Expressed at 10 hours and 12 hours in presumptive
CC diencephalon. Expressed transiently at 12 hours in caudal
CC telencephalon. Later expression in floor plate and somites, followed by
CC rostral telencephalon and ventral thalamus. Expressed at 40 hours in
CC hypothalamus.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AB006104; BAA21764.1; -; mRNA.
DR RefSeq; NP_571459.1; NM_131384.1.
DR AlphaFoldDB; O42115; -.
DR SMR; O42115; -.
DR STRING; 7955.ENSDARP00000075256; -.
DR PaxDb; O42115; -.
DR Ensembl; ENSDART00000080810; ENSDARP00000075256; ENSDARG00000058011.
DR GeneID; 30657; -.
DR KEGG; dre:30657; -.
DR CTD; 30657; -.
DR ZFIN; ZDB-GENE-990415-15; arxa.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160633; -.
DR HOGENOM; CLU_047013_7_0_1; -.
DR InParanoid; O42115; -.
DR OMA; RENAPFA; -.
DR OrthoDB; 944129at2759; -.
DR PhylomeDB; O42115; -.
DR TreeFam; TF350743; -.
DR PRO; PR:O42115; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000058011; Expressed in floor plate and 41 other tissues.
DR ExpressionAtlas; O42115; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IMP:ZFIN.
DR GO; GO:0003322; P:pancreatic A cell development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021539; P:subthalamus development; IMP:ZFIN.
DR GO; GO:0021537; P:telencephalon development; IMP:ZFIN.
DR GO; GO:0021794; P:thalamus development; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..453
FT /note="Aristaless-related homeobox protein"
FT /id="PRO_0000048818"
FT DNA_BIND 215..274
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 421..434
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 49396 MW; 547F7CC478534808 CRC64;
MSSQYDDDSR DRSECKSKSP TVLSSYCIDS ILGRRSPCKV RQLGAQSLPA PVRPDHEMTT
EVTSKENSFD SDMHLPPKLR RLYGPGGKYL DSGRGFHEHL EKGERERLLD QACESLKISQ
APQVSISRSK SYRENAPFSQ SDEGQSPEHM AQELVELSTL KFEEDVVKEE ACGDNSLSPK
DEESLHNDGD VKDGEDSVCL SAGSDSEEGM LKRKQRRYRT TFTSYQLEEL ERAFQKTHYP
DVFTREELAM RLDLTEARVQ VWFQNRRAKW RKREKAGVQA HPTGLPFPGP LAAAHPLSHY
LEGGPFPPHP HPALESAWTA AAAAAAAFPG LAPPPNSSAL PPATPLGLGT FLGTAMFRHP
AFIGPTFGRL FSSMGPLTSA STAAALLRQT APPVESPVQP SAALPEPPSS SSSTAADRRA
SSIAALRLKA KEHSAQLTQL NILPSGTAGK EVC
