ARX_MOUSE
ID ARX_MOUSE Reviewed; 564 AA.
AC O35085; A2A4G9; Q9QYT4;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Homeobox protein ARX;
DE AltName: Full=Aristaless-related homeobox;
GN Name=Arx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9256348; DOI=10.1016/s0925-4773(97)00062-2;
RA Miura H., Yanazawa M., Kato K., Kitamura K.;
RT "Expression of a novel aristaless related homeobox gene 'Arx' in the
RT vertebrate telencephalon, diencephalon and floor plate.";
RL Mech. Dev. 65:99-109(1997).
RN [2]
RP SEQUENCE REVISION TO 391 AND 442.
RA Kitamura K.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RA Ohsaki K.;
RT "Homeobox genes and nervous development.";
RL Thesis (1999), Nara Institute of Science and Technology, Japan.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcription factor required for normal brain development.
CC May be important for maintenance of specific neuronal subtypes in the
CC cerebral cortex and axonal guidance in the floor plate (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AB006103; BAA28284.2; -; mRNA.
DR EMBL; AB026674; BAA85852.1; -; Genomic_DNA.
DR EMBL; AL590876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052033; AAH52033.1; -; mRNA.
DR CCDS; CCDS30271.1; -.
DR RefSeq; NP_001292869.1; NM_001305940.1.
DR RefSeq; NP_031518.2; NM_007492.4.
DR AlphaFoldDB; O35085; -.
DR SMR; O35085; -.
DR STRING; 10090.ENSMUSP00000049039; -.
DR PhosphoSitePlus; O35085; -.
DR PaxDb; O35085; -.
DR PRIDE; O35085; -.
DR ProteomicsDB; 277241; -.
DR ABCD; O35085; 1 sequenced antibody.
DR Antibodypedia; 24612; 400 antibodies from 32 providers.
DR DNASU; 11878; -.
DR Ensembl; ENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277.
DR Ensembl; ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277.
DR GeneID; 11878; -.
DR KEGG; mmu:11878; -.
DR UCSC; uc009tsq.1; mouse.
DR CTD; 170302; -.
DR MGI; MGI:1097716; Arx.
DR VEuPathDB; HostDB:ENSMUSG00000035277; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160633; -.
DR HOGENOM; CLU_047013_7_0_1; -.
DR InParanoid; O35085; -.
DR OMA; RENAPFA; -.
DR OrthoDB; 944129at2759; -.
DR PhylomeDB; O35085; -.
DR TreeFam; TF350743; -.
DR BioGRID-ORCS; 11878; 1 hit in 58 CRISPR screens.
DR PRO; PR:O35085; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; O35085; protein.
DR Bgee; ENSMUSG00000035277; Expressed in rostral migratory stream and 96 other tissues.
DR Genevisible; O35085; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; IMP:MGI.
DR GO; GO:0021800; P:cerebral cortex tangential migration; IMP:MGI.
DR GO; GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; IMP:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0072148; P:epithelial cell fate commitment; IMP:MGI.
DR GO; GO:0030900; P:forebrain development; IMP:MGI.
DR GO; GO:0021759; P:globus pallidus development; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IMP:MGI.
DR GO; GO:0044241; P:lipid digestion; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0021772; P:olfactory bulb development; IMP:MGI.
DR GO; GO:0035265; P:organ growth; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR GO; GO:0046622; P:positive regulation of organ growth; IMP:MGI.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..564
FT /note="Homeobox protein ARX"
FT /id="PRO_0000048820"
FT DNA_BIND 330..389
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 532..545
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 160..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..252
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="D -> E (in Ref. 3; BAA85852)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="P -> H (in Ref. 3; BAA85852)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="S -> A (in Ref. 3; BAA85852)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="Missing (in Ref. 3; BAA85852)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="Missing (in Ref. 3; BAA85852)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 564 AA; 58490 MW; 74FEBBD3BA92B39C CRC64;
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRADQ
EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAATATGTA
GPRGEVPPPP PPAARPGERQ DSAGAVAAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP
FVPPPPALDE LSGPGGVAHP EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE
ELLEDDDEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ KTHYPDVFTR
EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL PFPGPLSATH PLSPYLDASP
FPPHHPALDS AWTAAAAAAA AAFPSLPPPP GSASLPPSGA PLGLSTFLGA AVFRHPAFIS
PAFGRLFSTM APLTSASTAA ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK
AKEHAAQLTQ LNILPGTSTG KEVC
