OPGD_SHIFL
ID OPGD_SHIFL Reviewed; 551 AA.
AC Q83R85;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Glucans biosynthesis protein D;
DE Flags: Precursor;
GN Name=mdoD; Synonyms=opgD; OrderedLocusNames=SF1786, S1488;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Probably involved in the control of the structural glucose
CC backbone of osmoregulated periplasmic glucans (OPGs). {ECO:0000250}.
CC -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC -!- PTM: Predicted to be exported by the Tat system. The position of the
CC signal peptide cleavage has not been experimentally proven.
CC -!- SIMILARITY: Belongs to the OpgD/OpgG family. {ECO:0000305}.
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DR EMBL; AE005674; AAN43355.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16873.1; -; Genomic_DNA.
DR RefSeq; NP_707648.1; NC_004337.2.
DR RefSeq; WP_000375966.1; NZ_WPGW01000106.1.
DR AlphaFoldDB; Q83R85; -.
DR SMR; Q83R85; -.
DR STRING; 198214.SF1786; -.
DR EnsemblBacteria; AAN43355; AAN43355; SF1786.
DR EnsemblBacteria; AAP16873; AAP16873; S1488.
DR GeneID; 1024950; -.
DR GeneID; 58391364; -.
DR KEGG; sfl:SF1786; -.
DR KEGG; sfx:S1488; -.
DR PATRIC; fig|198214.7.peg.2119; -.
DR HOGENOM; CLU_023403_2_0_6; -.
DR OMA; DVQFFHV; -.
DR OrthoDB; 1049230at2; -.
DR UniPathway; UPA00637; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR HAMAP; MF_01068; MdoD_OpgD; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR023724; Glucan_biosyn_MdoD.
DR InterPro; IPR014438; Glucan_biosyn_MdoG/MdoD.
DR InterPro; IPR007444; Glucan_biosyn_MdoG_C.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR019546; TAT_signal_bac_arc.
DR PANTHER; PTHR30504; PTHR30504; 1.
DR Pfam; PF04349; MdoG; 1.
DR PIRSF; PIRSF006281; MdoG; 1.
DR SUPFAM; SSF74650; SSF74650; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR TIGRFAMs; TIGR01409; TAT_signal_seq; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Periplasm; Reference proteome; Signal.
FT SIGNAL 1..32
FT /note="Tat-type signal"
FT /evidence="ECO:0000255"
FT CHAIN 33..551
FT /note="Glucans biosynthesis protein D"
FT /id="PRO_0000020215"
SQ SEQUENCE 551 AA; 62784 MW; 75045B672B8684FF CRC64;
MDRRRFIKGS MAMAAVCGTS GIASLFSQAA FAADSDIADG QTQRFDFSIL QSMAHDLAQT
AWRGAPRPLP DTLATMTPQA YNSIQYDAEK SLWHNVENRQ LDAQFFHMGM GFRRRVRMFS
VDPATHLARE IHFRPELFKY NDAGVDTKQL EGQSDLGFAG FRVFKAPELA RRDVVSFLGA
SYFRAVDDTY QYGLSARGLA IDTYTDSKEE FPDFTAFWFD TVKPGATTFT VYALLDSASI
TGAYKFTIHC EKSQVIMDVE NHLYARKDIK QLGISPMTSM FSCGTNERRM CDTIHPQIHD
SDRLSMWRGN GEWICRPLNN PQKLQFNAYT DNNPKGFGLL QLDRDFSHYQ DIMGWYNKRP
SLWVEPRNKW GKGTIGLMEI PTTGETLDNI VCFWQPEKAV KAGDEFAFQY RLYWSAQPPV
HCPLARVMAT RTGMGGFPEG WAPGEHYPEK WARRFAVDFV GGDLKAAAPK GIEPVITLSS
GEAKQIEILY IEPIDGYRIQ FDWYPTSDST DPVDMRMYLR CQGDAISETW LYQYFPPAPD
KRQYVDDRVM S