ARX_RAT
ID ARX_RAT Reviewed; 566 AA.
AC A6YP92;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Homeobox protein ARX;
DE AltName: Full=Aristaless-related homeobox;
GN Name=Arx {ECO:0000250|UniProtKB:Q96QS3};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:ABR27821.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar {ECO:0000312|EMBL:ABR27821.1};
RA Nardou R., Acquaviva L., Corby S., Khantane S., Represa A., Cardoso C.;
RT "ARX RNA interference in vivo induced cortical developmental disorders.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor required for normal brain development.
CC May be important for maintenance of specific neuronal subtypes in the
CC cerebral cortex and axonal guidance in the floor plate (By similarity).
CC {ECO:0000250|UniProtKB:Q96QS3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35137,
CC ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-
CC ProRule:PRU00138}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000255}.
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DR EMBL; EF638804; ABR27821.1; -; mRNA.
DR RefSeq; NP_001093644.1; NM_001100174.1.
DR AlphaFoldDB; A6YP92; -.
DR SMR; A6YP92; -.
DR STRING; 10116.ENSRNOP00000044306; -.
DR ABCD; A6YP92; 1 sequenced antibody.
DR Ensembl; ENSRNOT00000089828; ENSRNOP00000071239; ENSRNOG00000053562.
DR GeneID; 317268; -.
DR KEGG; rno:317268; -.
DR CTD; 170302; -.
DR RGD; 1562672; Arx.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160633; -.
DR InParanoid; A6YP92; -.
DR OrthoDB; 944129at2759; -.
DR PhylomeDB; A6YP92; -.
DR PRO; PR:A6YP92; -.
DR Proteomes; UP000002494; Chromosome X.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0007420; P:brain development; IEP:RGD.
DR GO; GO:0021846; P:cell proliferation in forebrain; ISO:RGD.
DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISO:RGD.
DR GO; GO:0021800; P:cerebral cortex tangential migration; ISO:RGD.
DR GO; GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; ISO:RGD.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0072148; P:epithelial cell fate commitment; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISO:RGD.
DR GO; GO:0021759; P:globus pallidus development; ISO:RGD.
DR GO; GO:0044241; P:lipid digestion; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0048666; P:neuron development; IEP:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0021772; P:olfactory bulb development; ISO:RGD.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0046622; P:positive regulation of organ growth; ISO:RGD.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..566
FT /note="Homeobox protein ARX"
FT /id="PRO_0000307920"
FT DNA_BIND 332..391
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 534..547
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 160..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..252
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 58647 MW; 399926C42A63B6AF CRC64;
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRTDQ
EKAMQGSPKG SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAAATATGT
AGPRGEVPPP PPPAARPGER QDSAGAVAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP
FVPPPPALDE LGGPGGVAHP EERLSAASGP GSAPAAGGGT GTEEDEEELL EDEEDEDEEE
ELLEDDEEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAAAVATEG GELSPKEELL
LHPEDAEGKD GEDSVCLSAG SDSEEGLLKR KQRRYRTTFT SYQLEELERA FQKTHYPDVF
TREELAMRLD LTEARVQVWF QNRRAKWRKR EKAGAQTHPP GLPFPGPLSA THPLSPYLDA
SPFPPHHPAL DSAWTAAAAA AAAAFPSLPP PPGSASLPPS GAPLGLSTFL GAAVFRHPAF
ISPAFGRLFS TMAPLTSAST AAALLRQPTP AVEGAVASGA LADPATAAAD RRASSIAALR
LKAKEHAAQL TQLNILPGTS TGKEVC
