ID   ARY1_BOVIN              Reviewed;         290 AA.
AC   Q1JPA6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Arylamine N-acetyltransferase 1;
DE            EC=2.3.1.5;
DE   AltName: Full=Arylamide acetylase 1;
DE   AltName: Full=N-acetyltransferase type 1;
DE            Short=NAT-1;
GN   Name=NAT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the detoxification of a plethora of hydrazine
CC       and arylamine drugs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA;
CC         Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BT025447; ABF57403.1; -; mRNA.
DR   EMBL; BC123764; AAI23765.1; -; mRNA.
DR   RefSeq; NP_001069040.1; NM_001075572.1.
DR   RefSeq; XP_005226217.1; XM_005226160.3.
DR   RefSeq; XP_005226218.1; XM_005226161.3.
DR   RefSeq; XP_005226219.1; XM_005226162.3.
DR   RefSeq; XP_005226220.1; XM_005226163.3.
DR   RefSeq; XP_005226221.1; XM_005226164.3.
DR   RefSeq; XP_010818673.1; XM_010820371.2.
DR   RefSeq; XP_010818674.1; XM_010820372.1.
DR   AlphaFoldDB; Q1JPA6; -.
DR   SMR; Q1JPA6; -.
DR   STRING; 9913.ENSBTAP00000045530; -.
DR   PaxDb; Q1JPA6; -.
DR   PRIDE; Q1JPA6; -.
DR   Ensembl; ENSBTAT00000048506; ENSBTAP00000045530; ENSBTAG00000016473.
DR   GeneID; 512603; -.
DR   KEGG; bta:512603; -.
DR   CTD; 9; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016473; -.
DR   eggNOG; ENOG502RD0D; Eukaryota.
DR   GeneTree; ENSGT00390000012054; -.
DR   HOGENOM; CLU_049918_3_0_1; -.
DR   InParanoid; Q1JPA6; -.
DR   OMA; CYEHNTL; -.
DR   OrthoDB; 1545569at2759; -.
DR   TreeFam; TF106311; -.
DR   Reactome; R-BTA-156582; Acetylation.
DR   Reactome; R-BTA-9753281; Paracetamol ADME.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000016473; Expressed in rumen papilla and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004060; F:arylamine N-acetyltransferase activity; IBA:GO_Central.
DR   InterPro; IPR001447; Arylamine_N-AcTrfase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR11786; PTHR11786; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Acyltransferase; Cytoplasm; Reference proteome; Transferase.
FT   CHAIN           1..290
FT                   /note="Arylamine N-acetyltransferase 1"
FT                   /id="PRO_0000284078"
FT   BINDING         103
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         106..107
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P18440"
SQ   SEQUENCE   290 AA;  34199 MW;  72E4A2B7C0F70F4C CRC64;
     MDIDAYFERI GYKNSRDKLD LETLTDILQH QIRAIPFENL NIHCGEAMEL DLEVIFDQIV
     RRKRGGWCLQ VNHLLYWALT MIGFETTILG GYVYNTFNDK YSSAMIHLLL KVTIDGRDYI
     ADAGFGRSYQ MWQPLELISG KYQPQTPCIF RLTEDRGTWY LDQIRREQYI PNQDFLDSDL
     LEKNEYRKIY SFTLEPRTIK DFESVNTYLQ ESPASVFTSK SFCSLQTPEG VHCLVGFTLT
     YRRFNYKDNT DLVEFKTLNE KEIEENLKNI FNISLEKKLT PKHGDKFFTI