OPGH_CAUVC
ID OPGH_CAUVC Reviewed; 663 AA.
AC Q9A6R5;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Glucans biosynthesis glucosyltransferase H {ECO:0000255|HAMAP-Rule:MF_01072};
DE EC=2.4.1.- {ECO:0000255|HAMAP-Rule:MF_01072};
GN Name=opgH {ECO:0000255|HAMAP-Rule:MF_01072}; OrderedLocusNames=CC_2018;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Involved in the biosynthesis of osmoregulated periplasmic
CC glucans (OPGs). {ECO:0000255|HAMAP-Rule:MF_01072}.
CC -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01072}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01072}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01072}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. OpgH
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01072}.
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DR EMBL; AE005673; AAK23993.1; -; Genomic_DNA.
DR PIR; E87499; E87499.
DR RefSeq; NP_420825.1; NC_002696.2.
DR RefSeq; WP_010919884.1; NC_002696.2.
DR AlphaFoldDB; Q9A6R5; -.
DR STRING; 190650.CC_2018; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR EnsemblBacteria; AAK23993; AAK23993; CC_2018.
DR KEGG; ccr:CC_2018; -.
DR PATRIC; fig|190650.5.peg.2038; -.
DR eggNOG; COG2943; Bacteria.
DR HOGENOM; CLU_015730_1_0_5; -.
DR OMA; TAGLHYW; -.
DR BioCyc; CAULO:CC2018-MON; -.
DR UniPathway; UPA00637; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.550.10; -; 1.
DR HAMAP; MF_01072; MdoH_OpgH; 1.
DR InterPro; IPR023725; Glucans_biosynth_gluTrFase_H.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF13632; Glyco_trans_2_3; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Glycosyltransferase; Membrane;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..663
FT /note="Glucans biosynthesis glucosyltransferase H"
FT /id="PRO_0000210348"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TRANSMEM 413..435
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TRANSMEM 470..492
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TRANSMEM 558..580
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TRANSMEM 584..606
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
SQ SEQUENCE 663 AA; 72443 MW; A57C91277B09CD96 CRC64;
MSDRSSLFDV RSSTSVTLDQ VVRRDTVEIP DEAALAMPVQ PLSFWQGGAR RATALTQDMN
LRRWMLGLMT IAMGVAGWKA SFDTIALGGV TRLEAVVLTL LAPLFLALSL WFCTALIGFV
VLMGRPKDPL GIDSEAPMPK LHTRTAILMP VYNEDAAAVF ARLRAMDASI AETGSARNFD
IFVISDTRDA QVALAEQACF ARFRREANCN VYYRIRKENT GRKAGNVADW VSRWGSAYEH
MLVLDADSLM TGEAMVRLAD AMERHPGAGL IQTMPMIING QTIFARTLQF ATRLYGRVAW
TGLAWWSGSE SSFWGHNAIV RTRAFAETCG LPHLPGPKPF GGEVMSHDAL ESALLRRGGW
SVHLAPYLDG SYEESPSNLL DFATRDRRWC RGNIQHVPLI ALPGLHWMSR MHLVIGVLSY
ALSPLWFFCL SAGLISRALM PELKKAAFTM ADLKAAAHAL IDWSEIQATA WAMIITFVLL
FGPKILGAIL VLARKGEVKG FGGKRRMAAG LGVEMLLSAL VAPMLMFTQT RAIVEILAGK
VGGWAAQRRD ADKVDFKEAW AAMGWISLSG LILAASFWFT PDLLTATAPI LAGLVLAVPL
TMLGAHKVAG LKLKANGLFM TPEERRPPAI VRAAVGAACE PPIRWFARNG RPIGPTTKIR
DAA