ID   OPGH_KLEP7              Reviewed;         842 AA.
AC   A6T7C6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Glucans biosynthesis glucosyltransferase H {ECO:0000255|HAMAP-Rule:MF_01072};
DE            EC=2.4.1.- {ECO:0000255|HAMAP-Rule:MF_01072};
GN   Name=mdoH {ECO:0000255|HAMAP-Rule:MF_01072};
GN   Synonyms=opgH {ECO:0000255|HAMAP-Rule:MF_01072};
GN   OrderedLocusNames=KPN78578_10360; ORFNames=KPN_01064;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the biosynthesis of osmoregulated periplasmic
CC       glucans (OPGs). {ECO:0000255|HAMAP-Rule:MF_01072}.
CC   -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01072}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01072}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01072}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. OpgH
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01072}.
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DR   EMBL; CP000647; ABR76497.1; -; Genomic_DNA.
DR   RefSeq; WP_012068545.1; NC_009648.1.
DR   AlphaFoldDB; A6T7C6; -.
DR   STRING; 272620.KPN_01064; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   jPOST; A6T7C6; -.
DR   PRIDE; A6T7C6; -.
DR   EnsemblBacteria; ABR76497; ABR76497; KPN_01064.
DR   KEGG; kpn:KPN_01064; -.
DR   HOGENOM; CLU_015730_1_0_6; -.
DR   OMA; TAGLHYW; -.
DR   UniPathway; UPA00637; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.550.10; -; 1.
DR   HAMAP; MF_01072; MdoH_OpgH; 1.
DR   InterPro; IPR023725; Glucans_biosynth_gluTrFase_H.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Glycosyltransferase; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..842
FT                   /note="Glucans biosynthesis glucosyltransferase H"
FT                   /id="PRO_1000064605"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        513..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        656..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        680..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
SQ   SEQUENCE   842 AA;  96082 MW;  55C85EE54E11621A CRC64;
     MNKITKYIDA LPLSDAEKSA LPDTSLQAVH QALDDDHQTF AREDDSPLGS VKARLAHSWP
     DSLSGDQLVK DDEGRTQLHA MPKAKRSSMI PDPWRTNPVG RFWDRLRGRD VTPRYLSRLT
     QEERESEQKW RTVGTIRRYI LLLLTLSQTV VATWYMKTIL PYQGWALINP ADMVGQNLWI
     SFMQLLPYVL QSGILILFAV LFCWVSAGFW TALMGFLQLL IGRDKYSISA STVGDEPLNP
     AHRTALIMPI CNEDVDRVFA GLRATWESVK ATGNAAHFDV YILSDSYNPD ICVAEQKAWM
     ELIAEVQGEG QIFYRRRRRR VKRKSGNIDD FCRRWGSQYS YMVVLDADSV MTGECLSSLV
     RLMEANPNAG IIQSSPRASG MDTLYARCQQ FATRVYGPLF TAGLHFWQLG ESHYWGHNAI
     IRVKPFIEHC ALAPLPGEGN FAGSILSHDF VEAALMRRAG WGVWIAYDLP GSYEELPPNL
     LDELKRDRRW CQGNLMNFRL FLVRGMHPVH RAVFLTGVMS YLSAPLWFMF LALSTALQVV
     HALTEPQYFL QPRQLFPVWP QWRPELAIAL FASTMVLLFL PKLLSIILVW CKGPKEYGGF
     FRVTLSLLLE VLFSVLLAPV RMLFHTVFVV SAFLGWEVVW NSPQRDDDST PWGEAFMRHG
     SQLLLGLVWA VGMAWLDLRF LFWLAPIVVS LILSPFVSAI SSRATVGLRT KRWKLFLIPE
     EYSPPQVLKD TDAYLTMNRQ RSLDDGFMHA VFNPSFNALA TAMATARHRQ GHILEIARER
     HVEQALNETP DKLNRDRRLV LLSDPVTMSR LHYRVWAAPE KYSSWVNAYQ QLALNPLALK
     TK