ID   ARY2_CALVI              Reviewed;         759 AA.
AC   P28514;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Arylphorin subunit C223;
DE   Flags: Precursor;
OS   Calliphora vicina (Blue blowfly) (Calliphora erythrocephala).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=7373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Fat body;
RX   PubMed=1711849; DOI=10.1016/0006-291x(91)90632-h;
RA   Naumann U., Scheller K.;
RT   "Complete cDNA and gene sequence of the developmentally regulated
RT   arylphorin of Calliphora vicina and its homology to insect hemolymph
RT   proteins and arthropod hemocyanins.";
RL   Biochem. Biophys. Res. Commun. 177:963-972(1991).
CC   -!- FUNCTION: Arylphorin is a larval storage protein (LSP) which may serve
CC       as a storage protein used primarily as a source of aromatic amino acids
CC       for protein synthesis during metamorphosis. It is a constituent of the
CC       sclerotizing system of the cuticle, and serves as a carrier for
CC       ecdysteroid hormone.
CC   -!- SUBUNIT: Heterohexamer.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Fat body.
CC   -!- SIMILARITY: Belongs to the hemocyanin family. {ECO:0000305}.
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DR   EMBL; M76479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X59390; CAA42033.1; -; Genomic_DNA.
DR   PIR; JQ1044; JQ1044.
DR   AlphaFoldDB; P28514; -.
DR   SMR; P28514; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   Gene3D; 1.20.1370.10; -; 1.
DR   Gene3D; 2.60.40.1520; -; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11511; PTHR11511; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 2.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48050; SSF48050; 1.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Storage protein.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..759
FT                   /note="Arylphorin subunit C223"
FT                   /id="PRO_0000013332"
SQ   SEQUENCE   759 AA;  92525 MW;  8E66CC7A2D71352D CRC64;
     MKIAIVLLAI VGLAASASIT DKKVKIADKD FLAKQKFLFE IVYRVEDPLM FEEWIKMGKS
     FTFDKADYNH FDMYMDKFYE AYKYGAILPK GEFFYYAKNW EVFQRNVAFA RMHCNEGMFV
     YALTLAVIHR DDFHGLILPS IYEIFPQYFF NSKFVYEAEK FDYDVWSKYI MYEKEYKDIL
     YKDYATFYKN HDNHYYYFFT KDFKTYQWWK MMGLGEHWYS EDRFMLRDNM DKYNKDSKYL
     EIFEGTKMFF MPVDYTRDIE FFNKESALSY FTEDVGFNAY WYYLNMDYAF FLDGKTYGLN
     KDRRGEYWLY NVRQLLSRYY MERLSHGFGE IPAFSFIDSI EYGYNPQLVY HNGVGFSYRK
     NYYEVESFGK FDYFYKVLDF FNRMDEIITK GVYVTYDGKT IDLRKPESIE YIGSIMQGNV
     DTLHSYFFKY WYMFAHMYLA YDNTQTLQVF PHIFLNYETS MRDPMFYMFY KKIASVYFQF
     FNYVKPYTHE ELLFPGVTIK DVKVSELVTY FDLVDFDVTN LMNDKMTFVD GQFVWDKTLL
     ARQMRLNHKP FDFDFVIESD KAQKVVIRTY LGPKYDEFGR VISLTENREN FMELDSFLYT
     LKSGVNEFKR YSKDFYWTVE DRTTYTELYK YVMLALQGKY DFPLDISEPH CGFPDRLVLP
     HGWYKGMPMQ FFFYVTPFTT EYEQFSTYDY SYSCGLGSGV RYIDETCFGY PFDREIDEYE
     FFVPNMYFKD VKIFHQDTFE KYFEHKYEKF GHFDYNYHH