OPGH_SALTY
ID OPGH_SALTY Reviewed; 847 AA.
AC Q8ZQ26;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Glucans biosynthesis glucosyltransferase H {ECO:0000255|HAMAP-Rule:MF_01072};
DE EC=2.4.1.- {ECO:0000255|HAMAP-Rule:MF_01072};
GN Name=mdoH {ECO:0000255|HAMAP-Rule:MF_01072};
GN Synonyms=opgH {ECO:0000255|HAMAP-Rule:MF_01072}; OrderedLocusNames=STM1151;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Involved in the biosynthesis of osmoregulated periplasmic
CC glucans (OPGs). {ECO:0000255|HAMAP-Rule:MF_01072}.
CC -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01072}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01072}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01072}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. OpgH
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01072}.
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DR EMBL; AE006468; AAL20081.1; -; Genomic_DNA.
DR RefSeq; NP_460122.1; NC_003197.2.
DR RefSeq; WP_001044610.1; NC_003197.2.
DR AlphaFoldDB; Q8ZQ26; -.
DR STRING; 99287.STM1151; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR PaxDb; Q8ZQ26; -.
DR EnsemblBacteria; AAL20081; AAL20081; STM1151.
DR GeneID; 1252669; -.
DR KEGG; stm:STM1151; -.
DR PATRIC; fig|99287.12.peg.1218; -.
DR HOGENOM; CLU_015730_0_0_6; -.
DR OMA; TAGLHYW; -.
DR PhylomeDB; Q8ZQ26; -.
DR BioCyc; SENT99287:STM1151-MON; -.
DR UniPathway; UPA00637; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016758; F:hexosyltransferase activity; IBA:GO_Central.
DR GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.550.10; -; 1.
DR HAMAP; MF_01072; MdoH_OpgH; 1.
DR InterPro; IPR023725; Glucans_biosynth_gluTrFase_H.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Glycosyltransferase; Membrane;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..847
FT /note="Glucans biosynthesis glucosyltransferase H"
FT /id="PRO_0000210362"
FT TOPO_DOM 1..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..156
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 157..193
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 217..511
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..534
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 535..567
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 591..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 626..679
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..702
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT TOPO_DOM 703..847
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 847 AA; 97101 MW; 25B37C9DA304C126 CRC64;
MNKTTEYIDA LLLSEREKAA LPKTDIRAVH QALDAEHRTY SREDDSPQGS VKARLEHAWP
DSLAKGQLIK DDEGRDQLQA MPKATRSSMF PDPWRTNPVG RFWDRLRGRD VTPRYVSRLT
KEEQASEQKW RTVGTIRRYI LLILTLAQTV VATWYMKTIL PYQGWALINP MDMVGQDIWV
SFMQLLPYML QTGILILFAV LFCWVSAGFW TALMGFLQLL IGRDKYSISA STVGDEPLNP
EHRTALIMPI CNEDVSRVFA GLRATWESVK ATGNAAHFDV YILSDSYNPD ICVAEQKAWM
ELIAEVQGEG QIFYRRRRRR MKRKSGNIDD FCRRWGNQYS YMVVLDADSV MSGECLSGLV
RLMEANPNAG IIQSSPKASG MDTLYARCQQ FATRVYGPLF TAGLHFWQLG ESHYWGHNAI
IRVKPFIEHC ALAPLPGEGS FAGSILSHDF VEAALMRRAG WGVWIAYDLP GSYEELPPNL
LDELKRDRRW CHGNLMNFRL FLVKGMHPVH RAVFLTGVMS YLSAPLWFMF LALSTALQVV
HALTEPQYFL QPRQLFPVWP QWRPELAIAL FASTMVLLFL PKLLSIMLIW CKGTKEYGGF
WRVTLSLLLE VLFSVLLAPV RMLFHTVFVV SAFLGWEVVW NSPQRDDDST PWGEAFMRHG
SQLLLGLVWA VGMAWLDLRF LFWLAPIVFS LILSPFVSVI SSRSTVGLRT KRWKLFLIPE
EYSPPQVLVD TDKYLEMNRR RILDDGFMHA VFNPSLNALA TAMATARHRA SKVLEIARDR
HVEQALNETP EKLNRDRRLV LLSDPVTMAR LHYRVWNAPE RYSSWVNHYQ SLVLNPQALQ
GRTSSAR
