ID   ARY2_CHICK              Reviewed;         290 AA.
AC   P13914;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Arylamine N-acetyltransferase, pineal gland isozyme NAT-3;
DE            Short=Arylamine acetylase;
DE            EC=2.3.1.5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Pineal gland;
RX   PubMed=2583181; DOI=10.1111/j.1432-1033.1989.tb15110.x;
RA   Ohtomi M., Sasaki M., Deguchi T.;
RT   "Two arylamine N-acetyltransferases from chicken pineal gland as identified
RT   by cDNA cloning.";
RL   Eur. J. Biochem. 185:253-261(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA;
CC         Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X17480; CAA35515.1; -; mRNA.
DR   PIR; S06652; XYCHY3.
DR   RefSeq; NP_001004373.1; NM_001004373.1.
DR   RefSeq; XP_015148014.1; XM_015292528.1.
DR   RefSeq; XP_015148015.1; XM_015292529.1.
DR   AlphaFoldDB; P13914; -.
DR   SMR; P13914; -.
DR   STRING; 9031.ENSGALP00000008779; -.
DR   PaxDb; P13914; -.
DR   Ensembl; ENSGALT00000008793; ENSGALP00000008779; ENSGALG00000005473.
DR   GeneID; 415809; -.
DR   KEGG; gga:415809; -.
DR   CTD; 415809; -.
DR   VEuPathDB; HostDB:geneid_415809; -.
DR   eggNOG; ENOG502RD0D; Eukaryota.
DR   GeneTree; ENSGT00390000012054; -.
DR   HOGENOM; CLU_049918_3_0_1; -.
DR   InParanoid; P13914; -.
DR   OrthoDB; 1545569at2759; -.
DR   PhylomeDB; P13914; -.
DR   TreeFam; TF106311; -.
DR   Reactome; R-GGA-156582; Acetylation.
DR   Reactome; R-GGA-9753281; Paracetamol ADME.
DR   PRO; PR:P13914; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000005473; Expressed in granulocyte and 11 other tissues.
DR   ExpressionAtlas; P13914; baseline and differential.
DR   GO; GO:0004060; F:arylamine N-acetyltransferase activity; IBA:GO_Central.
DR   InterPro; IPR001447; Arylamine_N-AcTrfase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR11786; PTHR11786; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..290
FT                   /note="Arylamine N-acetyltransferase, pineal gland isozyme
FT                   NAT-3"
FT                   /id="PRO_0000107902"
FT   ACT_SITE        68
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        107
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        122
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  33664 MW;  F73F0E2D29C9A270 CRC64;
     MDIKEYFARI SYGGSYEKPD LETLTEIFQH HIQAVPFENL SIHCGETIEL DLAATYDKIV
     RKKRGGWCME NNHLLSWALK TLGYNVTLLG AKVYIPEHDA YADDIDHLLL KVVLHDKSYI
     VDGGFGMAYQ LWQPMELISG KDQPQTPGIF RFVEENGTWY LEKVKRKQYV PNHSDSAPHN
     VDKEVCRRVY LFTLQPRDIE EFRARNLHLQ TAPDSLFVTK SICSLQTPDG VRALVGWKLT
     EIKYNYKDNM DLVEIRILAD EEMEKTLKEK FNITLDKKFV PINTSRLSLF