ID   OPIP1_AMBTS             Reviewed;           9 AA.
AC   P84814;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   11-DEC-2019, entry version 14.
DE   RecName: Full=Opioid peptide;
OS   Amblyomma testudinarium (Hard tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Amblyomminae; Amblyomma.
OX   NCBI_TaxID=375577;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=CNS {ECO:0000269|PubMed:15752574};
RX   PubMed=15752574; DOI=10.1016/j.peptides.2004.11.003;
RA   Liang J.-G., Zhang J., Lai R., Rees H.H.;
RT   "An opioid peptide from synganglia of the tick, Amblyomma testindinarium.";
RL   Peptides 26:603-606(2005).
CC   -!- FUNCTION: Has opiate-like activity. Decreases nociception-related
CC       behavior in a dose dependent fashion when administered to mice. May
CC       play a role in down-regulating the host defense and immune response
CC       during feeding. {ECO:0000269|PubMed:15752574}.
CC   -!- TISSUE SPECIFICITY: Expressed in the synganglia (at protein level).
CC       {ECO:0000269|PubMed:15752574}.
CC   -!- MASS SPECTROMETRY: Mass=1136.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15752574};
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DR   GO; GO:0001515; F:opioid peptide activity; IDA:UniProtKB.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Opioid peptide.
FT   PEPTIDE         1..9
FT                   /note="Opioid peptide"
FT                   /evidence="ECO:0000269|PubMed:15752574"
FT                   /id="PRO_0000235909"
SQ   SEQUENCE   9 AA;  1136 MW;  D6EF21B3677B42D2 CRC64;
     LVVYPWTKM