OPN4L_DANRE
ID OPN4L_DANRE Reviewed; 500 AA.
AC Q1JPS6; Q8AV31;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Melanopsin-like;
DE AltName: Full=Melanopsin;
DE AltName: Full=Opsin-4-like;
GN Name=opn4l; Synonyms=opn4c, opn4m2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL82577.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Retina {ECO:0000312|EMBL:AAL82577.1};
RX PubMed=12487121; DOI=10.1016/s0169-328x(02)00454-0;
RA Bellingham J., Whitmore D., Philp A.R., Wells D.J., Foster R.G.;
RT "Zebrafish melanopsin: isolation, tissue localisation and phylogenetic
RT position.";
RL Brain Res. Mol. Brain Res. 107:128-136(2002).
RN [2] {ECO:0000312|EMBL:AAI16615.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Photoreceptor implicated in non-image-forming responses to
CC light. {ECO:0000250|UniProtKB:Q9QXZ9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of retinal horizontal cells.
CC {ECO:0000269|PubMed:12487121}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY078161; AAL82577.1; -; mRNA.
DR EMBL; BC116614; AAI16615.1; -; mRNA.
DR RefSeq; NP_840074.2; NM_178289.3.
DR AlphaFoldDB; Q1JPS6; -.
DR SMR; Q1JPS6; -.
DR STRING; 7955.ENSDARP00000002787; -.
DR PaxDb; Q1JPS6; -.
DR Ensembl; ENSDART00000018501; ENSDARP00000002787; ENSDARG00000007553.
DR GeneID; 352918; -.
DR KEGG; dre:352918; -.
DR CTD; 352918; -.
DR ZFIN; ZDB-GENE-030314-2; opn4.1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234631; -.
DR HOGENOM; CLU_009579_3_12_1; -.
DR InParanoid; Q1JPS6; -.
DR OMA; VRTHEQM; -.
DR OrthoDB; 911005at2759; -.
DR PhylomeDB; Q1JPS6; -.
DR TreeFam; TF324998; -.
DR PRO; PR:Q1JPS6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000007553; Expressed in head and 13 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; IDA:ZFIN.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:ZFIN.
DR GO; GO:0008377; P:light-induced release of internally sequestered calcium ion; IDA:ZFIN.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chromophore; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..500
FT /note="Melanopsin-like"
FT /id="PRO_0000270989"
FT TOPO_DOM 1..65
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 404..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 330
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 137..215
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 185
FT /note="L -> F (in Ref. 1; AAL82577)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="V -> L (in Ref. 1; AAL82577)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="S -> SH (in Ref. 1; AAL82577)"
FT /evidence="ECO:0000305"
FT CONFLICT 452
FT /note="S -> P (in Ref. 1; AAL82577)"
FT /evidence="ECO:0000305"
FT CONFLICT 471
FT /note="I -> V (in Ref. 1; AAL82577)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 54490 MW; 4D0895F1CAAA12B2 CRC64;
MSHHSSWRGH HCAPGDINCT AGFKESLGSR NYKLLHVPVH GPTHSHHHDP PHPFPTVDVP
DHAHYIIGSV ILIVGITGVI GNALVVYVFC RSRTLRTAGN MFIVNLAVAD FLMSVTQSPV
FFAASLHRRW VFGERPCELY AFCGALFGIC SMMTLTAIAA DRCLAITQPL ALVSRVSRRK
AGAVLVVVWL YSLGWSLPPF FGWSAYVPEG LQTSCSWDYM TFTPSVRAYT ILLFVFVFFI
PLGIIGSCYF AIFQTIRAAG KEIRELDCGE THKVYERMQN EWKMAKVALV VIVLFIISWS
PYSVVALTAT AGYSHFLTPY MNSVPAVIAK ASAIHNPIIY AITHPKYRVA IARYIPVLRP
ILRVKEKDLR SSFSSGSVSS RRPTLTSQCS LGVSMGNAAR ANGRWGKTRL SSASDSDSCW
TESEADGSSV SSLTFGRRVS TEISTDTVIL SSGSSVSNAS GQKSERAHKV ISVPVPSITF
ETDAADGESL SDGKALLGGN
