ID   OPN4_RUTRU              Reviewed;         500 AA.
AC   Q6XL69;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Melanopsin;
DE   AltName: Full=Opsin-4;
GN   Name=opn4;
OS   Rutilus rutilus (Roach).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Leuciscidae; Leuciscinae; Rutilus.
OX   NCBI_TaxID=48668;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAO38857.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Retina {ECO:0000312|EMBL:AAO38857.1};
RX   PubMed=12906786; DOI=10.1016/s0960-9822(03)00509-8;
RA   Jenkins A., Munoz M., Tarttelin E.E., Bellingham J., Foster R.G.,
RA   Hankins M.W.;
RT   "VA opsin, melanopsin, and an inherent light response within retinal
RT   interneurons.";
RL   Curr. Biol. 13:1269-1278(2003).
CC   -!- FUNCTION: Photoreceptor implicated in non-image-forming responses to
CC       light. {ECO:0000250|UniProtKB:Q9QXZ9}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in a subset of retinal horizontal cells
CC       as well as in retinal ganglion cells. {ECO:0000269|PubMed:12906786}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY226847; AAO38857.1; -; mRNA.
DR   AlphaFoldDB; Q6XL69; -.
DR   SMR; Q6XL69; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001760; Opsin.
DR   InterPro; IPR027430; Retinal_BS.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chromophore; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Photoreceptor protein; Receptor; Retinal protein;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..500
FT                   /note="Melanopsin"
FT                   /id="PRO_0000270992"
FT   TOPO_DOM        1..65
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..101
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..232
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..286
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        308..322
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        344..500
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          406..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         330
FT                   /note="N6-(retinylidene)lysine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        137..215
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   500 AA;  54523 MW;  86B0D626B48DF427 CRC64;
     MSHHSSWRGH HCAPGDNNCT AGFKESLGSK NYKLLHVPFH GPTHSHHHEP PHPFPTVDVP
     DHAHYIIGAV ILIVGITGVI GNALVIYVFC RSRTLRTAGN MFVVNLAVAD FFMSLTQSPV
     FFAASLHRRW IFGERICELY AFCGALFGIC SMMTLTAIAA DRCLAITQPL ALVGNVSRRK
     AGAVLAVVWL YSLGWSLPPF FGWSAYVPEG LQTSCSWDYM TFTPSVRAYT ILLFIFVFFI
     PLGIIVSCYV GIFQAIRAMG KEIRELDCGE TQKVYERMQN EWKMAKIALL VILLFVISWS
     PYSVVALTAT AGYSHLLTPY MNSVPAVIAK ASAIHNPIIY AITHPKYRAA IARYIPVLRT
     ILRVKEKELR SSFSSGSVSS RRPTLSSQCS LGVSIGNAAR ANGRWGKKRL SSASDSDSCW
     TESEADGSSV SSLTFGRRVS TEISTDTVIL SPGSSNSTAS GQKSEKAHKV VSVPVPSITF
     ETDSADESLS DGKALLLGGN