OPP23_HAEIF
ID OPP23_HAEIF Reviewed; 385 AA.
AC P46025;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Outer membrane protein P2;
DE Short=OMP P2;
DE Flags: Precursor;
GN Name=ompP2;
OS Haemophilus influenzae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B1, B2, B3, B4, and D1;
RX PubMed=8022287; DOI=10.1111/j.1365-2958.1994.tb00394.x;
RA Duim B., van Alphen L., Eijk P., Jansen H.M., Dankert J.;
RT "Antigenic drift of non-encapsulated Haemophilus influenzae major outer
RT membrane protein P2 in patients with chronic bronchitis is caused by point
RT mutations.";
RL Mol. Microbiol. 11:1181-1189(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B1, B2, B3, B4, and D1;
RX PubMed=8412618; DOI=10.1006/mpat.1993.1044;
RA Duim B., Dankert J., Jansen H.M., van Alphen L.;
RT "Genetic analysis of the diversity in outer membrane protein P2 of non-
RT encapsulated Haemophilus influenzae.";
RL Microb. Pathog. 14:451-462(1993).
CC -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC across the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: The sequence of strain B1 is shown here.
CC -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR EMBL; X73380; CAA51797.1; -; Genomic_DNA.
DR EMBL; X73381; CAA51798.1; -; Genomic_DNA.
DR EMBL; X73382; CAA51799.1; -; Genomic_DNA.
DR EMBL; X73384; CAA51801.1; -; Genomic_DNA.
DR EMBL; X73385; CAA51802.1; -; Genomic_DNA.
DR PIR; S68066; S68066.
DR PIR; S68067; S68067.
DR PIR; S68070; S68070.
DR AlphaFoldDB; P46025; -.
DR SMR; P46025; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR CDD; cd00342; gram_neg_porins; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR033900; Gram_neg_porin_domain.
DR InterPro; IPR023614; Porin_dom_sf.
DR Pfam; PF13609; Porin_4; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..20
FT CHAIN 21..385
FT /note="Outer membrane protein P2"
FT /id="PRO_0000025260"
FT VARIANT 190
FT /note="R -> G (in strain: B4)"
FT VARIANT 237
FT /note="G -> S (in strain: B4)"
FT VARIANT 280
FT /note="T -> A (in strain: B4)"
FT VARIANT 281
FT /note="D -> N (in strain: B2 and B3)"
FT VARIANT 285
FT /note="G -> D (in strain: D1)"
FT VARIANT 286
FT /note="S -> N (in strain: B3 and B4)"
FT VARIANT 296
FT /note="E -> K (in strain: B2, B3 and B4)"
SQ SEQUENCE 385 AA; 41787 MW; 0B6B3B0F40734811 CRC64;
MKKTLAALIV GAFAASAANA AVVYNNEGTN VELGGRLSII TEQSNSTVDD QEQQHGALRN
AGSRFHIKAT HNFGDGFYAQ GYLETRLVSD YPESSSDHFG GITTKYAYVT LGNKAFGEVK
LGRAKTIADG ITSAEDKEYG VLNNKKYIPT NGNTVGYTYK GIDGLDGLVL GANYLLAQSR
VPGGPSPFPR KQGEVYPQQI SNGVQVGAKY DANNIIAGIA FGRTNYKTAG ADFDPYGDFG
LGRKEQVEGV LSTLGYRFSD LGLLVSLDSG YAKTKYYTTT DSSSGSQTIT NPAYDEKRSF
VSPGFQYELM EDTNVYGNFK YERTSVNQGK NTREQAVLFG VDHKLHKQVL TYIEGAYART
KTNDKGKTEK TGKEKSVGVG LRVYF
