ID   OPP24_HAEIF             Reviewed;         386 AA.
AC   P46026;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Outer membrane protein P2;
DE            Short=OMP P2;
DE   Flags: Precursor;
GN   Name=ompP2;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=D2, D3, D3R, and D4;
RX   PubMed=8022287; DOI=10.1111/j.1365-2958.1994.tb00394.x;
RA   Duim B., van Alphen L., Eijk P., Jansen H.M., Dankert J.;
RT   "Antigenic drift of non-encapsulated Haemophilus influenzae major outer
RT   membrane protein P2 in patients with chronic bronchitis is caused by point
RT   mutations.";
RL   Mol. Microbiol. 11:1181-1189(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=D2, D3, D3R, and D4;
RX   PubMed=8412618; DOI=10.1006/mpat.1993.1044;
RA   Duim B., Dankert J., Jansen H.M., van Alphen L.;
RT   "Genetic analysis of the diversity in outer membrane protein P2 of non-
RT   encapsulated Haemophilus influenzae.";
RL   Microb. Pathog. 14:451-462(1993).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: The sequence of strain D2/D3R is shown here.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X73376; CAA51793.1; -; Genomic_DNA.
DR   EMBL; X73377; CAA51794.1; -; Genomic_DNA.
DR   EMBL; X73378; CAA51795.1; -; Genomic_DNA.
DR   EMBL; X73379; CAA51796.1; -; Genomic_DNA.
DR   PIR; S68062; S68062.
DR   AlphaFoldDB; P46026; -.
DR   SMR; P46026; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   Pfam; PF13609; Porin_4; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..20
FT   CHAIN           21..386
FT                   /note="Outer membrane protein P2"
FT                   /id="PRO_0000025261"
FT   VARIANT         284..285
FT                   /note="DD -> GG (in strain: D4)"
FT   VARIANT         284
FT                   /note="D -> G (in strain: D3)"
SQ   SEQUENCE   386 AA;  41906 MW;  05F8909A2382A1F3 CRC64;
     MKKTLAALIV GAFAASAANA AVVYNNEGTN VELGGRLSII TEQSNSTVDD QEQQHGALRN
     AGSRFHIKAT HNFGDGFYAQ GYLETRLVSD YPGSSSDHFG GITTKYAYVT LGNKAFGEVK
     LGRAKTIADG ITSAEDKEYG VLNNKKYILT NGNTVGYTYK GIDGLDGLVL GANYLLAQSR
     VPGGPGLFPR KQGEVYPQQI SNGVQVGAKY DANNIIAGIA FGRTNYKTAG ADFDFSDAFG
     LGRKEQVEGV LSTLGYRFSD LGLLVSLDSG YAKTKYHTTT TDSDDGRQTI TNPAYDEKRS
     FVSPGFQYEL MEDTNVYGNF KYERTSVNQG KNTREQAVLF GVDHKLHKQV LTYIEGAYAR
     TKTNDKGKTE KTGKEKSVGV GLRVYF