ID   OPP25_HAEIF             Reviewed;         371 AA.
AC   P46027;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Outer membrane protein P2;
DE            Short=OMP P2;
DE   Flags: Precursor;
GN   Name=ompP2;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T1, and T2;
RX   PubMed=8022287; DOI=10.1111/j.1365-2958.1994.tb00394.x;
RA   Duim B., van Alphen L., Eijk P., Jansen H.M., Dankert J.;
RT   "Antigenic drift of non-encapsulated Haemophilus influenzae major outer
RT   membrane protein P2 in patients with chronic bronchitis is caused by point
RT   mutations.";
RL   Mol. Microbiol. 11:1181-1189(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T1, and T2;
RX   PubMed=8412618; DOI=10.1006/mpat.1993.1044;
RA   Duim B., Dankert J., Jansen H.M., van Alphen L.;
RT   "Genetic analysis of the diversity in outer membrane protein P2 of non-
RT   encapsulated Haemophilus influenzae.";
RL   Microb. Pathog. 14:451-462(1993).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: The sequence of strain T1 is shown here.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; X73386; CAA51803.1; -; Genomic_DNA.
DR   EMBL; X73383; CAA51800.1; -; Genomic_DNA.
DR   PIR; S68069; S68069.
DR   PIR; S68072; S68072.
DR   AlphaFoldDB; P46027; -.
DR   SMR; P46027; -.
DR   TCDB; 1.B.1.3.1; the general bacterial porin (gbp) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   Pfam; PF13609; Porin_4; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..20
FT   CHAIN           21..371
FT                   /note="Outer membrane protein P2"
FT                   /id="PRO_0000025262"
FT   VARIANT         184
FT                   /note="K -> Q (in strain: T2)"
FT   VARIANT         224
FT                   /note="A -> T (in strain: T2)"
FT   VARIANT         273
FT                   /note="S -> T (in strain: T2)"
SQ   SEQUENCE   371 AA;  40902 MW;  D0F252D7A6E5CDA6 CRC64;
     MKKTLAALIV GAFAASAANA AVVYNNEGSK VELGGRLSVI AEQSNNTVDD QKQQHGALRN
     QGSRFHIKAT HNFGDGFYAQ GYLETRFISH YQDNADHFDD ITTKYAYVTL GNKAFGEVKL
     GRAKTIADDI TSAEDKEYGV LNNSKYIRTN GNTVGYTFKG IDGLVLGANY LLAQARDTAN
     PGKKGEVAAQ SISNGVQVGA KYDANNIVAG IAYGRTNYRK NIIAPKQNLG RKDQVEGVLS
     TLGYHFSDLG LLVSLDSGYA KTKYYEQQQQ QRSSPTKPRY DEKRYFVSPG FQYELMEDTN
     VYGNFKYERT SSDEGKKTRE QAVLFGVDHK LHKQVLTYIE GAYARTKTNG KGKAETTGKE
     KSVGVGLRVY F