ID   ARY3_DICDI              Reviewed;         306 AA.
AC   Q54IU7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Probable arylamine N-acetyltransferase 3;
DE            EC=2.3.1.5;
DE   AltName: Full=Arylamide acetylase 3;
DE   AltName: Full=N-acetyltransferase type 3;
DE            Short=NAT-3;
GN   ORFNames=DDB_G0288509;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA;
CC         Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000113; EAL63188.1; -; Genomic_DNA.
DR   RefSeq; XP_636691.1; XM_631599.1.
DR   AlphaFoldDB; Q54IU7; -.
DR   SMR; Q54IU7; -.
DR   PaxDb; Q54IU7; -.
DR   EnsemblProtists; EAL63188; EAL63188; DDB_G0288509.
DR   GeneID; 8626663; -.
DR   KEGG; ddi:DDB_G0288509; -.
DR   dictyBase; DDB_G0288509; nat1.
DR   eggNOG; ENOG502RI6E; Eukaryota.
DR   HOGENOM; CLU_049918_4_0_1; -.
DR   InParanoid; Q54IU7; -.
DR   OMA; HMINIIN; -.
DR   PhylomeDB; Q54IU7; -.
DR   PRO; PR:Q54IU7; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0004060; F:arylamine N-acetyltransferase activity; IBA:GO_Central.
DR   InterPro; IPR001447; Arylamine_N-AcTrfase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR11786; PTHR11786; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..306
FT                   /note="Probable arylamine N-acetyltransferase 3"
FT                   /id="PRO_0000327946"
FT   ACT_SITE        75
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        115
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        130
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   306 AA;  34708 MW;  A6B46552DA1FF4B5 CRC64;
     MEAISIFSDY QLQFFKRIGM KPKPIETLDD VSDVMKACSN VFSFENLDIV SNSCEPLNKD
     VLIKQVICNN QGGLCYKINT LLYHFLLEFG FKIHIIRGSV ENQETHSDWN IPTGHMINII
     NFENRLYVVD VAFGCNLSLR PIPITDDGSE VVESCTGLYR VRKVENCVSG KYNYTHILEH
     RKLDSFLIES GKTWVTGYAF DPLLIVDNNN NNEKTTHQTL VQQLVIDDPT KEFSTKPLAT
     KIVNDGSSFS IATLTANSFT LTDCKTGQKT KTNFDNDKSS FEQFNQHLIS IFNLPPLKTI
     PPIFLN