OPPA_LACLS
ID OPPA_LACLS Reviewed; 600 AA.
AC Q02VA9; Q09144;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Oligopeptide-binding protein OppA;
DE Flags: Precursor;
GN Name=oppA; OrderedLocusNames=LACR_D17;
OS Lactococcus lactis subsp. cremoris (strain SK11).
OG Plasmid pSK11L, and Plasmid pLACR4.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=272622;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC PLASMID=pSK11L;
RX PubMed=8586224;
RA Yu W., Gillies K., Kondo J.K., Broadbent J.R., McKay L.L.;
RT "Plasmid-mediated oligopeptide transport system in lactococci.";
RL Dev. Biol. Stand. 85:509-521(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK11; PLASMID=pLACR4;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- FUNCTION: This protein is a component of the oligopeptide permease, a
CC binding protein-dependent transport system, it binds peptides up to
CC five amino acids long with high affinity.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC {ECO:0000305}.
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DR EMBL; U09553; AAB00537.1; -; Unassigned_DNA.
DR EMBL; CP000429; ABJ74113.1; -; Genomic_DNA.
DR RefSeq; WP_011669110.1; NC_008506.1.
DR AlphaFoldDB; Q02VA9; -.
DR SMR; Q02VA9; -.
DR EnsemblBacteria; ABJ74113; ABJ74113; LACR_D17.
DR KEGG; llc:LACR_D17; -.
DR HOGENOM; CLU_017028_8_0_9; -.
DR OMA; FYNIDDW; -.
DR Proteomes; UP000000240; Plasmid pLACR4.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProt.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR030678; Peptide/Ni-bd.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR023765; SBP_5_CS.
DR InterPro; IPR000914; SBP_5_dom.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR PIRSF; PIRSF002741; MppA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS01040; SBP_BACTERIAL_5; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Peptide transport;
KW Plasmid; Protein transport; Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000305"
FT CHAIN 23..600
FT /note="Oligopeptide-binding protein OppA"
FT /id="PRO_0000272022"
FT LIPID 23
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 23
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CONFLICT 173
FT /note="A -> T (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="A -> V (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="K -> E (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="F -> I (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="A -> Y (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="A -> D (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="H -> R (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="W -> L (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="S -> A (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 559
FT /note="V -> I (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 564..566
FT /note="SLS -> MLN (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
FT CONFLICT 585
FT /note="D -> N (in Ref. 1; AAB00537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 600 AA; 65621 MW; 8F97856E92197FE4 CRC64;
MNKLKVTLLA SSVVLAATLL SACGSNQSSS TSTKKLKAGN FDVAYQNPDK AIKGGNLKVA
YQSDSPMKAQ WLSGLSNDAT FATMSGPGGG QDGLFFTDSG FKFIKGGAAD VALDKESKTA
TITLRKDLKW SDGSEVTAKD YEFTYETIAN PAYGSDRWTD SLANIVGLSD YHAGKAKTIS
GITFPDGENG KVIKVQFKEM KPGMTQSGNG YFLETVAPYQ YLKDVAPKDL ASSPKTTTKP
LVTGPFKPEN VVAGESIKYV PNPYYWGKKP KLNSITYEVV STAKSVAALS SSKYDFINGM
VSSQYKQVKN LKGYKVLGQQ AMAISLMYYN LGHYDAKNSI NVQDRKTPLQ DQNVRQAIGY
ARNVAEVANK FSNGLSTPAN SLIPPIFKQF TSSSVKGYEK QDLDKANKLL DEDGWKLNKS
TGYREKDGKE LSLVYAAHVG DANAETIAQN YIQQWKKIGV KVSLYNGKLM EFNSWVDHMT
TPPGANDWDI TDGSWSLASE PSQQDLFSAS APYNFGHFND SEITKDLNDI DSAKSENPTY
RKAAFVKYQE DMNKKAYVVP TNFSLSYTPV NKRVVGMTLD YGAMDTWSEI GVSSAKLATK
