ID   OPPF_STRP1              Reviewed;         307 AA.
AC   P0A2V6; Q490U6; Q9F5U1;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Oligopeptide transport ATP-binding protein OppF;
GN   Name=oppF; OrderedLocusNames=SPy_0297, M5005_Spy0253;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A-20 / Serotype M1,T1;
RA   Lin S.T., Wang C.H., Wu J.J.;
RT   "The oligopeptide permease oppF gene of Streptococcus pyogenes.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       oligopeptides. Probably responsible for energy coupling to the
CC       transport system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AF305548; AAG32327.1; -; Genomic_DNA.
DR   EMBL; AE004092; AAK33364.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50872.1; -; Genomic_DNA.
DR   RefSeq; NP_268643.1; NC_002737.2.
DR   AlphaFoldDB; P0A2V6; -.
DR   SMR; P0A2V6; -.
DR   STRING; 1314.HKU360_00292; -.
DR   PaxDb; P0A2V6; -.
DR   EnsemblBacteria; AAK33364; AAK33364; SPy_0297.
DR   GeneID; 57852082; -.
DR   KEGG; spy:SPy_0297; -.
DR   KEGG; spz:M5005_Spy0253; -.
DR   PATRIC; fig|160490.10.peg.261; -.
DR   HOGENOM; CLU_000604_1_23_9; -.
DR   OMA; VACHWAE; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013563; Oligopep_ABC_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08352; oligo_HPY; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Peptide transport; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..307
FT                   /note="Oligopeptide transport ATP-binding protein OppF"
FT                   /id="PRO_0000092665"
FT   DOMAIN          6..251
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         42..49
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   307 AA;  34716 MW;  DB55C3F0E2FECDC6 CRC64;
     MSEKLVEVKD LEISFGEGKK KFVAVKNANF FIKKGETFSL VGESGSGKTT IGRAIIGLND
     TSSGQILYDG KVINGRKSKS EANELIRKIQ MIFQDPAASL NERATVDYII SEGLYNFNLF
     KTEEERKEKI KNMMAEVGLL SEHLTRYPHE FSGGQRQRIG IARALVMNPE FVIADEPISA
     LDVSVRAQVL NLLKRMQAEK GLTYLFIAHD LSVVRFISDR IAVIHKGVIV EVAETEELFN
     NPIHPYTQSL LSAVPIPDPI LERQKELVVY HPDQHDYTLD KPSMVEIKPN HFVWANQAEI
     EKYQKEL