ID   OPPF_STRP8              Reviewed;         307 AA.
AC   Q8P2L5;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Oligopeptide transport ATP-binding protein OppF;
GN   Name=oppF; OrderedLocusNames=spyM18_0285;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       oligopeptides. Probably responsible for energy coupling to the
CC       transport system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AE009949; AAL97060.1; -; Genomic_DNA.
DR   RefSeq; WP_011017336.1; NC_003485.1.
DR   AlphaFoldDB; Q8P2L5; -.
DR   SMR; Q8P2L5; -.
DR   KEGG; spm:spyM18_0285; -.
DR   HOGENOM; CLU_000604_1_23_9; -.
DR   OMA; VACHWAE; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013563; Oligopep_ABC_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08352; oligo_HPY; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Peptide transport; Protein transport; Transport.
FT   CHAIN           1..307
FT                   /note="Oligopeptide transport ATP-binding protein OppF"
FT                   /id="PRO_0000092668"
FT   DOMAIN          6..251
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         42..49
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   307 AA;  34774 MW;  42715000DE0D02FA CRC64;
     MSEKLVEVKD LEISFGEGKK KFVAVKNANF FIKKGETFSL VGESGSGKTT IGRAIIGLND
     TSSGQILYDG KVINGRKSKS EANELIRKIQ MIFQDPAASL NERATVDYII SEGLYNFNLF
     KTEEERKEKI KNMMAEVGLL SEHLTRYPHE FSGGQRQRIG IARALVMNPE FVIADEPISA
     LDVSVRAQVL NLLKRMQAEK DLTYLFIAHD LSVVRFISDR IAVIHKGVIV EVAETEELFN
     NPIHPYTQSL LSAVPIPDPI LERQKELVVY HPDQHDYTLD KPSMVEIKPN HFVWANQAEI
     EKYQKEL