位置:首页 > 蛋白库 > ARYL_CHICK
ARYL_CHICK
ID   ARYL_CHICK              Reviewed;         287 AA.
AC   P12275;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Arylamine N-acetyltransferase, liver isozyme;
DE            Short=Arylamine acetylase;
DE            EC=2.3.1.5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=2897360; DOI=10.1016/s0021-9258(18)68531-x;
RA   Ohsako S., Ohtomi M., Sakamoto Y., Uyemura K., Deguchi T.;
RT   "Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and
RT   expression in Chinese hamster ovary cells.";
RL   J. Biol. Chem. 263:7534-7538(1988).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2897359; DOI=10.1016/s0021-9258(18)68530-8;
RA   Deguchi T., Sakamoto Y., Sasaki Y., Uyemura K.;
RT   "Arylamine N-acetyltransferase from chicken liver. I. Monoclonal
RT   antibodies, immunoaffinity purification, and amino acid sequences.";
RL   J. Biol. Chem. 263:7528-7533(1988).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA;
CC         Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; J03737; AAA48590.1; -; mRNA.
DR   PIR; A28168; A28168.
DR   RefSeq; NP_990857.2; NM_205526.2.
DR   AlphaFoldDB; P12275; -.
DR   SMR; P12275; -.
DR   STRING; 9031.ENSGALP00000008778; -.
DR   PaxDb; P12275; -.
DR   GeneID; 396537; -.
DR   KEGG; gga:396537; -.
DR   CTD; 396537; -.
DR   VEuPathDB; HostDB:geneid_396537; -.
DR   eggNOG; ENOG502RVZB; Eukaryota.
DR   OrthoDB; 1545569at2759; -.
DR   PhylomeDB; P12275; -.
DR   PRO; PR:P12275; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0004060; F:arylamine N-acetyltransferase activity; IBA:GO_Central.
DR   InterPro; IPR001447; Arylamine_N-AcTrfase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR11786; PTHR11786; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Direct protein sequencing; Reference proteome;
KW   Transferase.
FT   CHAIN           1..287
FT                   /note="Arylamine N-acetyltransferase, liver isozyme"
FT                   /id="PRO_0000107900"
FT   ACT_SITE        68
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        107
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        122
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   287 AA;  32915 MW;  6E2919AD2979E210 CRC64;
     MNIQEYFSRI SFDGSHKDAD LQTLTAIFQH HIQAIPFENL SMHCGETIDL DLQATYNKIV
     KKKRGGWCME TNYLLFWALK EMGYDICVLG GNSYEPAKKA YTDEINHILL KVVIKGSSYI
     VDAGFGGGPY QTWLPMLLIS GKDQPQIPGI FRFIEDNGIW YLEKVKRKHY VPEGSVPLTD
     NPEMGNIRKL YSFTLEPKHI DDFQELNAYL QVAPDTILQK KSICSLQTTD GFYALVGWTF
     SEMKYKYKED ADLLQTTTLT DEEVEKTLKD KFNIVLENKL IPVNVRG
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024