ARYL_CHICK
ID ARYL_CHICK Reviewed; 287 AA.
AC P12275;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Arylamine N-acetyltransferase, liver isozyme;
DE Short=Arylamine acetylase;
DE EC=2.3.1.5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=2897360; DOI=10.1016/s0021-9258(18)68531-x;
RA Ohsako S., Ohtomi M., Sakamoto Y., Uyemura K., Deguchi T.;
RT "Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and
RT expression in Chinese hamster ovary cells.";
RL J. Biol. Chem. 263:7534-7538(1988).
RN [2]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=2897359; DOI=10.1016/s0021-9258(18)68530-8;
RA Deguchi T., Sakamoto Y., Sasaki Y., Uyemura K.;
RT "Arylamine N-acetyltransferase from chicken liver. I. Monoclonal
RT antibodies, immunoaffinity purification, and amino acid sequences.";
RL J. Biol. Chem. 263:7528-7533(1988).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA;
CC Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;
CC -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC {ECO:0000305}.
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DR EMBL; J03737; AAA48590.1; -; mRNA.
DR PIR; A28168; A28168.
DR RefSeq; NP_990857.2; NM_205526.2.
DR AlphaFoldDB; P12275; -.
DR SMR; P12275; -.
DR STRING; 9031.ENSGALP00000008778; -.
DR PaxDb; P12275; -.
DR GeneID; 396537; -.
DR KEGG; gga:396537; -.
DR CTD; 396537; -.
DR VEuPathDB; HostDB:geneid_396537; -.
DR eggNOG; ENOG502RVZB; Eukaryota.
DR OrthoDB; 1545569at2759; -.
DR PhylomeDB; P12275; -.
DR PRO; PR:P12275; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0004060; F:arylamine N-acetyltransferase activity; IBA:GO_Central.
DR InterPro; IPR001447; Arylamine_N-AcTrfase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR11786; PTHR11786; 1.
DR Pfam; PF00797; Acetyltransf_2; 1.
DR PRINTS; PR01543; ANATRNSFRASE.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Direct protein sequencing; Reference proteome;
KW Transferase.
FT CHAIN 1..287
FT /note="Arylamine N-acetyltransferase, liver isozyme"
FT /id="PRO_0000107900"
FT ACT_SITE 68
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000250"
FT ACT_SITE 107
FT /evidence="ECO:0000250"
FT ACT_SITE 122
FT /evidence="ECO:0000250"
SQ SEQUENCE 287 AA; 32915 MW; 6E2919AD2979E210 CRC64;
MNIQEYFSRI SFDGSHKDAD LQTLTAIFQH HIQAIPFENL SMHCGETIDL DLQATYNKIV
KKKRGGWCME TNYLLFWALK EMGYDICVLG GNSYEPAKKA YTDEINHILL KVVIKGSSYI
VDAGFGGGPY QTWLPMLLIS GKDQPQIPGI FRFIEDNGIW YLEKVKRKHY VPEGSVPLTD
NPEMGNIRKL YSFTLEPKHI DDFQELNAYL QVAPDTILQK KSICSLQTTD GFYALVGWTF
SEMKYKYKED ADLLQTTTLT DEEVEKTLKD KFNIVLENKL IPVNVRG