ID   OPR_OCTVU               Reviewed;         419 AA.
AC   Q5W9T5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Octopressin receptor;
GN   Name=OPR {ECO:0000312|EMBL:BAD67172.1};
GN   Synonyms=OTR {ECO:0000312|EMBL:BAD67168.1};
OS   Octopus vulgaris (Common octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=6645;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAD67172.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Vein {ECO:0000312|EMBL:BAD67172.1};
RX   PubMed=15504101; DOI=10.1042/bj20041230;
RA   Kanda A., Satake H., Kawada T., Minakata H.;
RT   "Novel evolutionary lineages of the invertebrate oxytocin/vasopressin
RT   superfamily peptides and their receptors in the common octopus (Octopus
RT   vulgaris).";
RL   Biochem. J. 387:85-91(2005).
CC   -!- FUNCTION: Acts as a receptor for octopressin.
CC       {ECO:0000269|PubMed:15504101}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Present in the nervous system and peripheral
CC       tissues. {ECO:0000269|PubMed:15504101}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; AB116233; BAD67168.1; -; mRNA.
DR   EMBL; AB158497; BAD67172.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5W9T5; -.
DR   SMR; Q5W9T5; -.
DR   PRIDE; Q5W9T5; -.
DR   Proteomes; UP000515154; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:UniProtKB.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..419
FT                   /note="Octopressin receptor"
FT                   /id="PRO_0000235830"
FT   TOPO_DOM        1..37
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..329
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        351..419
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          253..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..182
FT                   /evidence="ECO:0000250|UniProtKB:P34981,
FT                   ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   419 AA;  47505 MW;  FE5F6BE53476DA17 CRC64;
     MENFTEENLH PWITTTTRVY NNVTIFPQYD DELGKFEIMV LCILCFMALF GNAVVLIVLR
     IKKTTLTRMQ LLIVYLSVTD ISVALFHILP TIILKINVYF LGDISACRVY QFITVAELYA
     SSFVLIVTAL DRYISICHPL AAHMWTNRRV HMTTALALFL ALMCSLPQLD AVLVDFHGGK
     LCRPNLTTEL ANIAYSWWAF CSVFFVPLLL LIFFYGRICF VVWQSMRGRE CTQSVGSSAS
     RYVRKPIKCR ISSQTSSENR VKNYSDARDK DSSRNPRAIC RGVSKSKIKT IKLTFSVVAC
     FIICYTPFFT VLMARTYDAE LSSAQTPALV ILSLLPSLNS CTNPWIYLAF SGKVWCRQQS
     QNFPRTWTQT TNTYLVELEA KKRTSFGAEH VTFASNSTAR KTLNVDDTNT TALMSSSPC