ID   OPS2_BEAB2              Reviewed;         350 AA.
AC   J5J924;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=MFS transporter OpS2 {ECO:0000303|PubMed:26305932};
DE   AltName: Full=Oosporein biosynthesis protein 2 {ECO:0000303|PubMed:26305932};
GN   Name=OpS2 {ECO:0000303|PubMed:26305932}; ORFNames=BBA_08180;
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860;
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.-H., Zheng P., Wang Z.-L., Zhang S., Xie X.-Q., Shang Y.,
RA   St Leger R.J., Zhao G.-P., Wang C., Feng M.-G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=26305932; DOI=10.1073/pnas.1503200112;
RA   Feng P., Shang Y., Cen K., Wang C.;
RT   "Fungal biosynthesis of the bibenzoquinone oosporein to evade insect
RT   immunity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:11365-11370(2015).
CC   -!- FUNCTION: MFS transporter; part of the gene cluster that mediates the
CC       biosynthesis of the bibenzoquinone oosporein, a metabolite required for
CC       fungal virulence that acts by evading host immunity to facilitate
CC       fungal multiplication in insects (PubMed:26305932). The function of
CC       this putative MFS transporter remains unclear since its deletion leads
CC       to increased oosporein production (PubMed:26305932).
CC       {ECO:0000269|PubMed:26305932}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulated by the oosporein cluster
CC       specific regulator OpS3 that binds the promoter at a 5'-CGGA-3' motif
CC       (PubMed:26305932). {ECO:0000269|PubMed:26305932}.
CC   -!- DISRUPTION PHENOTYPE: Significantly increases oosporein production
CC       (PubMed:26305932). {ECO:0000269|PubMed:26305932}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH725181; EJP62793.1; -; Genomic_DNA.
DR   RefSeq; XP_008601499.1; XM_008603277.1.
DR   AlphaFoldDB; J5J924; -.
DR   STRING; 655819.J5J924; -.
DR   EnsemblFungi; EJP62793; EJP62793; BBA_08180.
DR   GeneID; 19891192; -.
DR   HOGENOM; CLU_008455_8_5_1; -.
DR   InParanoid; J5J924; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..350
FT                   /note="MFS transporter OpS2"
FT                   /id="PRO_0000438573"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  37991 MW;  E8FB3CD176F422E1 CRC64;
     MRFLAGGASA SVAAVGAGTV ADLWEVKRRG TAMGYFFLGP MLGPLVSPII GGILTQRFGW
     RSTQWGAVVY GGLVWLSMIF LLPETSSKAV KGKEPAVAEN SDDGNVQPVP ESCVSRFFKA
     LGRMLVEPFR LVGYLRSPPL FMTCYYASIS FACYYILNLA IQRTFSRDPY SFRAIILGLL
     YIPSALGSIV ASVVGGRWTD YVMRREAKAA GRFDESGNPK FRPSDRMCEN AWIPAFVFPA
     ALLVFGWTTH EGIFWFAPIV VTFFFGLGNS LIFNTATTML TEILPGKASN AVALNNLMRN
     TLSCAAAVAT DPLLGAIGTQ WLFTGLAVIC WASSGVIWAL KRHSDKAPSA